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2017 ; 2017
(ä): 7432739
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Comparison of Progression Rate of Retinal Pigment Epithelium Loss in Patients
with Neovascular Age-Related Macular Degeneration Treated with Ranibizumab and
Aflibercept
#MMPMID28316836
Wons J
; Wirth MA
; Graf N
; Becker MD
; Michels S
J Ophthalmol
2017[]; 2017
(ä): 7432739
PMID28316836
show ga
Purpose. Retinal pigment epithelium (RPE) loss in neovascular age-related macular
degeneration (nAMD) seem to have a linear progression but might be influenced by
the treatment. The purpose of the study is the comparison of RPE loss over three
years in patients treated with intravitreal ranibizumab to patients who were
switched to aflibercept. Methods. A retrospective analysis with 96 eyes switched
to aflibercept was conducted. The progression rate of RPE loss was evaluated in
patients who showed atrophy one year prior to switch (n = 17) or on switch date
(n = 19). The RPE loss was evaluated by spectral domain optical coherence
tomography (SD-OCT). Further, 22 eyes from patients treated with ranibizumab were
compared. Results. The median yearly progression of RPE loss after square root
transformation showed no significant difference in the year prior to switch
compared to the year after switch (p = 0.854). In patients who received only
ranibizumab, the median yearly progression of RPE loss was 0.15?mm/y, for
aflibercept patients, 0.13?mm/y. This difference was not statistically
significant (p = 0.172). Conclusions. There seems to be a linear progression rate
of RPE loss in patients treated with ranibizumab as well as in patients with
aflibercept. No significant increase of progression rate was found after switch
to aflibercept.