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10.1038/ncomms14639 http://scihub22266oqcxt.onion/10.1038/ncomms14639 C5338022!5338022 !28256511     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28256511 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (ä): 14639 Nephropedia Template TP {{tp|p=28256511 |t=2017. Zyxin regulates endothelial von Willebrand factor secretion by reorganizing actin filaments around exocytic granules |pdf=|usr=}}{{28256511 }} gab.com Text Zyxin regulates endothelial von Willebrand factor secretion by reorganizing actin filaments around exocytic granules JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28256511 #FOAvip Endothelial exocytosis of Weibel-Palade body (WPB) is one of the first lines of defence against vascular injury. However, the mechanisms that control WPB exocytosis in the final stages (including the docking, priming and fusion of granules) are poorly understood. Here we show that the focal adhesion protein zyxin is crucial in this process. Zyxin downregulation inhibits the secretion of von Willebrand factor (VWF), the most abundant cargo in WPBs, from human primary endothelial cells (ECs) induced by cAMP agonists. Zyxin-deficient mice exhibit impaired epinephrine-stimulated VWF release, prolonged bleeding time and thrombosis, largely due to defective endothelial secretion of VWF. Using live-cell super-resolution microscopy, we visualize previously unappreciated reorganization of pre-existing actin filaments around WPBs before fusion, dependent on zyxin and an interaction with the actin crosslinker ?-actinin. Our findings identify zyxin as a physiological regulator of endothelial exocytosis through reorganizing local actin network in the final stage of exocytosis. Twit Text FOAVip Zyxin regulates endothelial von Willebrand factor secretion by reorganizing actin filaments around exocytic granules ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28256511 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28256511 #FOAvip English Wikipedia <ref>{{Cite pmid|28256511 }}</ref> Zyxin regulates endothelial von Willebrand factor secretion by reorganizing actin filaments around exocytic granules #MMPMID28256511 Han X ; Li P ; Yang Z ; Huang X ; Wei G ; Sun Y ; Kang X ; Hu X ; Deng Q ; Chen L ; He A ; Huo Y ; Li D ; Betzig E ; Luo J Nat Commun 2017[Mar]; 8 (ä): 14639 PMID28256511 show ga Endothelial exocytosis of Weibel-Palade body (WPB) is one of the first lines of defence against vascular injury. However, the mechanisms that control WPB exocytosis in the final stages (including the docking, priming and fusion of granules) are poorly understood. Here we show that the focal adhesion protein zyxin is crucial in this process. Zyxin downregulation inhibits the secretion of von Willebrand factor (VWF), the most abundant cargo in WPBs, from human primary endothelial cells (ECs) induced by cAMP agonists. Zyxin-deficient mice exhibit impaired epinephrine-stimulated VWF release, prolonged bleeding time and thrombosis, largely due to defective endothelial secretion of VWF. Using live-cell super-resolution microscopy, we visualize previously unappreciated reorganization of pre-existing actin filaments around WPBs before fusion, dependent on zyxin and an interaction with the actin crosslinker ?-actinin. Our findings identify zyxin as a physiological regulator of endothelial exocytosis through reorganizing local actin network in the final stage of exocytosis. |Actin Cytoskeleton/*metabolism [MESH] |Actinin/metabolism [MESH] |Animals [MESH] |Bleeding Time [MESH] |Colforsin/pharmacology [MESH] |Cyclic AMP/agonists [MESH] |Endothelial Cells/drug effects/*metabolism [MESH] |Epinephrine/pharmacology [MESH] |Exocytosis/drug effects/*physiology [MESH] |HEK293 Cells [MESH] |Human Umbilical Vein Endothelial Cells [MESH] |Humans [MESH] |Intravital Microscopy [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Primary Cell Culture [MESH] |RNA, Small Interfering/metabolism [MESH] |Thrombosis/pathology [MESH] |Weibel-Palade Bodies/metabolism [MESH] |Zyxin/*physiology [MESH]Zyxin regulates endothelial von Willebrand factor secretion by reorgan(epmc).pdf DeepDyve Pubget Overpricing