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10.1038/srep43578 http://scihub22266oqcxt.onion/10.1038/srep43578 C5338015!5338015!28262829     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28262829|t=2017. Exosomes function in antigen presentation during an in vivo Mycobacterium tuberculosis infection |pdf=|usr=}}{{28262829}} gab.com Text Exosomes function in antigen presentation during an in vivo Mycobacterium tuberculosis infection JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28262829 #FOAvip Mycobacterium tuberculosis-infected macrophages and dendritic cells are limited in their ability to present antigen to CD4+ T cells suggesting that other mechanism of antigen presentation are driving the robust T cell response observed during an M. tuberculosis infection. These mechanisms could include antigens present in apoptotic bodies, necrotic debris, exosomes or even release of non-vesicular antigen from infected cells. However, there is limited data to support any of these mechanisms as important in driving T cell activation in vivo. In the present study we use Rab27a-deficient mice which show diminished trafficking of mycobacterial components to exosomes as well as M. tuberculosis strains that express recombinant proteins which traffic or fail to traffic to exosomes. We observed that exosomes released during a mouse M. tuberculosis infection contribute significantly to its T cell response. These finding imply that exosomes function to promote T cell immunity during a bacterial infection and are an important source of extracellular antigen. Twit Text FOAVip Exosomes function in antigen presentation during an in vivo Mycobacterium tuberculosis infection ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28262829 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28262829 #FOAvip English Wikipedia <ref>{{Cite pmid|28262829}}</ref> Exosomes function in antigen presentation during an in vivo Mycobacterium tuberculosis infection #MMPMID28262829 Smith VL; Cheng Y; Bryant BR; Schorey JS Sci Rep 2017[]; 7 (ä): ä PMID28262829show ga Mycobacterium tuberculosis-infected macrophages and dendritic cells are limited in their ability to present antigen to CD4+ T cells suggesting that other mechanism of antigen presentation are driving the robust T cell response observed during an M. tuberculosis infection. These mechanisms could include antigens present in apoptotic bodies, necrotic debris, exosomes or even release of non-vesicular antigen from infected cells. However, there is limited data to support any of these mechanisms as important in driving T cell activation in vivo. In the present study we use Rab27a-deficient mice which show diminished trafficking of mycobacterial components to exosomes as well as M. tuberculosis strains that express recombinant proteins which traffic or fail to traffic to exosomes. We observed that exosomes released during a mouse M. tuberculosis infection contribute significantly to its T cell response. These finding imply that exosomes function to promote T cell immunity during a bacterial infection and are an important source of extracellular antigen. äExosomes function in antigen presentation during an in vivo Mycobacter(epmc).pdf DeepDyve Pubget Overpricing