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10.1038/ncomms14644 http://scihub22266oqcxt.onion/10.1038/ncomms14644 C5337993!5337993 !28248292     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28248292 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (ä): 14644 Nephropedia Template TP {{tp|p=28248292 |t=2017. Potassium channels Kv1 3 and KCa3 1 cooperatively and compensatorily regulate antigen-specific memory T cell functions |pdf=|usr=}}{{28248292 }} gab.com Text Potassium channels Kv1 3 and KCa3 1 cooperatively and compensatorily regulate antigen-specific memory T cell functions JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28248292 #FOAvip Voltage-gated Kv1.3 and Ca(2+)-dependent KCa3.1 are the most prevalent K(+) channels expressed by human and rat T cells. Despite the preferential upregulation of Kv1.3 over KCa3.1 on autoantigen-experienced effector memory T cells, whether Kv1.3 is required for their induction and function is unclear. Here we show, using Kv1.3-deficient rats, that Kv1.3 is involved in the development of chronically activated antigen-specific T cells. Several immune responses are normal in Kv1.3 knockout (KO) rats, suggesting that KCa3.1 can compensate for the absence of Kv1.3 under these specific settings. However, experiments with Kv1.3 KO rats and Kv1.3 siRNA knockdown or channel-specific inhibition of human T cells show that maximal T-cell responses against autoantigen or repeated tetanus toxoid stimulations require both Kv1.3 and KCa3.1. Finally, our data also suggest that T-cell dependency on Kv1.3 or KCa3.1 might be irreversibly modulated by antigen exposure. Twit Text FOAVip Potassium channels Kv1 3 and KCa3 1 cooperatively and compensatorily regulate antigen-specific memory T cell functions ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28248292 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28248292 #FOAvip English Wikipedia <ref>{{Cite pmid|28248292 }}</ref> Potassium channels Kv1 3 and KCa3 1 cooperatively and compensatorily regulate antigen-specific memory T cell functions #MMPMID28248292 Chiang EY ; Li T ; Jeet S ; Peng I ; Zhang J ; Lee WP ; DeVoss J ; Caplazi P ; Chen J ; Warming S ; Hackos DH ; Mukund S ; Koth CM ; Grogan JL Nat Commun 2017[Mar]; 8 (ä): 14644 PMID28248292 show ga Voltage-gated Kv1.3 and Ca(2+)-dependent KCa3.1 are the most prevalent K(+) channels expressed by human and rat T cells. Despite the preferential upregulation of Kv1.3 over KCa3.1 on autoantigen-experienced effector memory T cells, whether Kv1.3 is required for their induction and function is unclear. Here we show, using Kv1.3-deficient rats, that Kv1.3 is involved in the development of chronically activated antigen-specific T cells. Several immune responses are normal in Kv1.3 knockout (KO) rats, suggesting that KCa3.1 can compensate for the absence of Kv1.3 under these specific settings. However, experiments with Kv1.3 KO rats and Kv1.3 siRNA knockdown or channel-specific inhibition of human T cells show that maximal T-cell responses against autoantigen or repeated tetanus toxoid stimulations require both Kv1.3 and KCa3.1. Finally, our data also suggest that T-cell dependency on Kv1.3 or KCa3.1 might be irreversibly modulated by antigen exposure. |*Immunologic Memory/drug effects [MESH] |Animals [MESH] |Epitopes/*immunology [MESH] |Gene Knockdown Techniques [MESH] |Humans [MESH] |Immunity/drug effects [MESH] |Intermediate-Conductance Calcium-Activated Potassium Channels/deficiency/*metabolism [MESH] |Kv1.3 Potassium Channel/*metabolism [MESH] |Lymphocyte Activation/immunology [MESH] |Phenotype [MESH] |Potassium Channel Blockers/pharmacology [MESH] |RNA, Small Interfering/metabolism [MESH] |Rats [MESH]Potassium channels Kv1 3 and KCa3 1 cooperatively and compensatorily r(epmc).pdf DeepDyve Pubget Overpricing