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10.1002/2211-5463.12190 http://scihub22266oqcxt.onion/10.1002/2211-5463.12190 C5337900!5337900!28286736     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       FEBS+Open+Bio 2017 ; 7 (3): 405-13 Nephropedia Template TP {{tp|p=28286736|t=2017. Overexpression of heparanase attenuated TGF???stimulated signaling in tumor cells |pdf=|usr=}}{{28286736}} gab.com Text Overexpression of heparanase attenuated TGF stimulated signaling in tumor cells JO: FEBS Open Bio http://www.kidney.de/pget.php?&tw=1&pmid=28286736 #FOAvip Heparan sulfate (HS) mediates the activity of various growth factors including TGF??. Heparanase is an endo?glucuronidase that specifically cleaves and modifies HS structure. In this study, we examined the effect of heparanase expression on TGF??1?dependent signaling activities. We found that overexpression of heparanase in human tumor cells (i.e., Fadu pharyngeal carcinoma, MCF7 breast carcinoma) attenuated TGF??1?stimulated Smad phosphorylation and led to a slower cell proliferation. TGF??1?stimulated Akt and Erk phosphorylation was also affected in the heparanase overexpression cells. This effect involved the enzymatic activity of heparanase, as overexpression of mutant inactive heparanase did not affect TGF??1 signaling activity. Analysis of HS isolated from Fadu cells revealed an increase in sulfation of the HS that had a rapid turnover in cells overexpressing heparanase. It appears that the structural alterations of HS affect the ability of TGF??1 to signal via its receptors and elicit a growth response. Given that heparanase expression promotes tumor growth in most cancers, this finding highlights a crosstalk between heparanase, HS, and TGF??1 function in tumorigenesis. Twit Text FOAVip Overexpression of heparanase attenuated TGF stimulated signaling in tumor cells ????FEBS Open Bio http://www.kidney.de/pget.php?&tw=1&pmid=28286736 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28286736 #FOAvip English Wikipedia <ref>{{Cite pmid|28286736}}</ref> Overexpression of heparanase attenuated TGF???stimulated signaling in tumor cells #MMPMID28286736 Batool T; Fang J; Barash U; Moustakas A; Vlodavsky I; Li J FEBS Open Bio 2017[Mar]; 7 (3): 405-13 PMID28286736show ga Heparan sulfate (HS) mediates the activity of various growth factors including TGF??. Heparanase is an endo?glucuronidase that specifically cleaves and modifies HS structure. In this study, we examined the effect of heparanase expression on TGF??1?dependent signaling activities. We found that overexpression of heparanase in human tumor cells (i.e., Fadu pharyngeal carcinoma, MCF7 breast carcinoma) attenuated TGF??1?stimulated Smad phosphorylation and led to a slower cell proliferation. TGF??1?stimulated Akt and Erk phosphorylation was also affected in the heparanase overexpression cells. This effect involved the enzymatic activity of heparanase, as overexpression of mutant inactive heparanase did not affect TGF??1 signaling activity. Analysis of HS isolated from Fadu cells revealed an increase in sulfation of the HS that had a rapid turnover in cells overexpressing heparanase. It appears that the structural alterations of HS affect the ability of TGF??1 to signal via its receptors and elicit a growth response. Given that heparanase expression promotes tumor growth in most cancers, this finding highlights a crosstalk between heparanase, HS, and TGF??1 function in tumorigenesis. äOverexpression of heparanase attenuated TGF???stimulated signaling in (epmc).pdf DeepDyve Pubget Overpricing