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10.1155/2017/6347138

http://scihub22266oqcxt.onion/10.1155/2017/6347138
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C5337890!5337890!28316834
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suck abstract from ncbi


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pmid28316834      J+Transplant 2017 ; 2017 (ä): ä
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  • The CECARI Study: Everolimus (Certican®) Initiation and Calcineurin Inhibitor Withdrawal in Maintenance Heart Transplant Recipients with Renal Insufficiency: A Multicenter, Randomized Trial #MMPMID28316834
  • Van Keer J; Derthoo D; Van Caenegem O; De Pauw M; Nellessen E; Duerinckx N; Droogne W; Vörös G; Meyns B; Belmans A; Janssens S; Van Cleemput J; Vanhaecke J
  • J Transplant 2017[]; 2017 (ä): ä PMID28316834show ga
  • In this 3-year, open-label, multicenter study, 57 maintenance heart transplant recipients (>1 year after transplant) with renal insufficiency (eGFR 30?60?mL/min/1.73?m2) were randomized to start everolimus with CNI withdrawal (N = 29) or continue their current CNI-based immunosuppression (N = 28). The primary endpoint, change in measured glomerular filtration rate (mGFR) from baseline to year 3, did not differ significantly between both groups (+7.0?mL/min in the everolimus group versus +1.9?mL/min in the CNI group, p = 0.18). In the on-treatment analysis, the difference did reach statistical significance (+9.4?mL/min in the everolimus group versus +1.9?mL/min in the CNI group, p = 0.047). The composite safety endpoint of all-cause mortality, major adverse cardiovascular events, or treated acute rejection was not different between groups. Nonfatal adverse events occurred in 96.6% of patients in the everolimus group and 57.1% in the CNI group (p < 0.001). Ten patients (34.5%) in the everolimus group discontinued the study drug during follow-up due to adverse events. The poor adherence to the everolimus therapy might have masked a potential benefit of CNI withdrawal on renal function.
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