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2017 ; 2017
(ä): 2796054
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A Descriptive Study of Open Fractures Contaminated by Seawater: Infection,
Pathogens, and Antibiotic Resistance
#MMPMID28303249
Zhu H
; Li X
; Zheng X
Biomed Res Int
2017[]; 2017
(ä): 2796054
PMID28303249
show ga
Aims. In this work, the main objectives were to investigate the clinical
characteristics and bacterial spectrum present in open fractures contaminated by
seawater. Methods. We conducted a retrospective cohort study and included all
patients with open fractures from 1st January, 2012, to 31st December, 2015, in
our hospital. Patients were grouped based on the presence of seawater
contamination in wounds. We compared the infection rate, bacterial spectrum, and
antibiotic resistance between the two groups. Results. We totally included 1337
cases of open fracture. Wounds from 107 cases (8.0%) were contaminated by
seawater. The wound infection rate of seawater-contaminated group was
significantly higher in patients with Gustilo-Anderson Type II and Type III open
fractures. The bacterial spectrum from seawater-contaminated wounds was
remarkably different from that of the remaining. Antibiotic sensitivity tests
revealed that more than 90% of infecting pathogens in seawater-contaminated
wounds were sensitive to levofloxacin and ciprofloxacin. Conclusion.
Cephalosporin in combination with quinolone was recommended in the early-stage
management of open fractures contaminated by seawater.