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2017 ; 56
(2
): 191-196
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Different Effects of Tolvaptan in Patients with Idiopathic Membranous Nephropathy
with Nephrotic Syndrome
#MMPMID28090051
Tanaka A
; Nakamura T
; Sato E
; Ueda Y
; Node K
Intern Med
2017[]; 56
(2
): 191-196
PMID28090051
show ga
This case report discusses the clinical indication for immunosuppressants in
patients with idiopathic membranous nephropathy (IMN). Because this disease
occasionally shows spontaneous remission, it is necessary to determine the
predictive values for a therapeutic effect in order to provide appropriate
treatment. Two distinct cases described herein illustrate the different effects
of tolvaptan in responders and non-responders, according to the pre-treatment
levels of AQP-2 immunostaining in the samples from renal biopsy and urinary
levels of AQP-2 and osmolality, suggesting that these values may be useful
predictors of response to tolvaptan in patients with nephrotic IMN.
|Antidiuretic Hormone Receptor Antagonists/administration & dosage/therapeutic use
[MESH]
|Benzazepines/administration & dosage/therapeutic use
[MESH]