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10.1155/2017/9832430 http://scihub22266oqcxt.onion/10.1155/2017/9832430 C5337394!5337394 !28299347     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28299347 &cmd=llinks): Failed to open stream: HTTP request failed! 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Adrenomedullin Regulates IL-1? Gene Expression in F4/80+ Macrophages during Synovial Inflammation |pdf=|usr=}}{{28299347 }} gab.com Text Adrenomedullin Regulates IL-1 Gene Expression in F4/80+ Macrophages during Synovial Inflammation JO: J Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=28299347 #FOAvip Adrenomedullin (AM) plays an important role in the regulation of inflammatory processes; however, the role and expression of AM in synovial inflammation have not been determined. To investigate the expression and role of AM in inflamed synovial tissue (ST), the gene expression profiles of AM in the ST, including synovial macrophages and fibroblasts, of a murine patellar surgical dislocation model were characterized. In addition, the effects of interleukin- (IL-) 1? and AM in cultured synovial cells were also examined. CD11c(+) macrophages were found to be elevated in ST of the surgically dislocated patella. Higher gene expression of CD11c, IL-1?, AM, receptor activity-modifying proteins 2 (RAMP2), and 3 (RAMP3) was also observed in ST obtained from the dislocated side. AM expression was also significantly increased in synovial fibroblasts and macrophages in response to IL-1? treatment. Synovial macrophages also highly expressed RAMP3 compared to fibroblasts and this expression was further stimulated by exogenously added IL-1?. Further, the treatment of the F4/80-positive cell fraction obtained from ST with AM inhibited IL-1? expression. Taken together, these findings demonstrated that AM was produced by synovial fibroblasts and macrophages in inflamed ST and that increased levels of AM may exert anti-inflammatory effects on synovial macrophages. Twit Text FOAVip Adrenomedullin Regulates IL-1 Gene Expression in F4/80+ Macrophages during Synovial Inflammation ????J Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=28299347 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28299347 #FOAvip English Wikipedia <ref>{{Cite pmid|28299347 }}</ref> Adrenomedullin Regulates IL-1? Gene Expression in F4/80+ Macrophages during Synovial Inflammation #MMPMID28299347 Takano S ; Uchida K ; Miyagi M ; Inoue G ; Aikawa J ; Iwabuchi K ; Takaso M J Immunol Res 2017[]; 2017 (ä): 9832430 PMID28299347 show ga Adrenomedullin (AM) plays an important role in the regulation of inflammatory processes; however, the role and expression of AM in synovial inflammation have not been determined. To investigate the expression and role of AM in inflamed synovial tissue (ST), the gene expression profiles of AM in the ST, including synovial macrophages and fibroblasts, of a murine patellar surgical dislocation model were characterized. In addition, the effects of interleukin- (IL-) 1? and AM in cultured synovial cells were also examined. CD11c(+) macrophages were found to be elevated in ST of the surgically dislocated patella. Higher gene expression of CD11c, IL-1?, AM, receptor activity-modifying proteins 2 (RAMP2), and 3 (RAMP3) was also observed in ST obtained from the dislocated side. AM expression was also significantly increased in synovial fibroblasts and macrophages in response to IL-1? treatment. Synovial macrophages also highly expressed RAMP3 compared to fibroblasts and this expression was further stimulated by exogenously added IL-1?. Further, the treatment of the F4/80-positive cell fraction obtained from ST with AM inhibited IL-1? expression. Taken together, these findings demonstrated that AM was produced by synovial fibroblasts and macrophages in inflamed ST and that increased levels of AM may exert anti-inflammatory effects on synovial macrophages. |*Gene Expression Regulation [MESH] |Adrenomedullin/*genetics/*metabolism/pharmacology [MESH] |Animals [MESH] |Cells, Cultured [MESH] |Fibroblasts/immunology [MESH] |Gene Expression [MESH] |Humans [MESH] |Interleukin-1beta/*genetics/pharmacology [MESH] |Macrophages/*immunology [MESH] |Mice [MESH] |Patella/pathology [MESH] |Real-Time Polymerase Chain Reaction [MESH] |Receptor Activity-Modifying Protein 2/genetics [MESH] |Receptor Activity-Modifying Protein 3/genetics [MESH] |Synovial Membrane/cytology/*immunology/metabolism [MESH]Adrenomedullin Regulates IL-1? Gene Expression in F4/80+ Macrophages d(epmc).pdf DeepDyve Pubget Overpricing