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10.1155/2017/9453108 http://scihub22266oqcxt.onion/10.1155/2017/9453108 C5337393!5337393!28298931     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Stem+Cells+Int 2017 ; 2017 (ä): ä Nephropedia Template TP {{tp|p=28298931|t=2017. The Roles of Insulin-Like Growth Factors in Mesenchymal Stem Cell Niche |pdf=|usr=}}{{28298931}} gab.com Text The Roles of Insulin-Like Growth Factors in Mesenchymal Stem Cell Niche JO: Stem Cells Int http://www.kidney.de/pget.php?&tw=1&pmid=28298931 #FOAvip Many tissues contain adult mesenchymal stem cells (MSCs), which may be used in tissue regeneration therapies. However, the MSC availability in most tissues is limited which demands expansion in vitro following isolation. Like many developing cells, the state of MSCs is affected by the surrounding microenvironment, and mimicking this natural microenvironment that supports multipotent or differentiated state in vivo is essential to understand for the successful use of MSC in regenerative therapies. Many researchers are, therefore, optimizing cell culture conditions in vitro by altering growth factors, extracellular matrices, chemicals, oxygen tension, and surrounding pH to enhance stem cells self-renewal or differentiation. Insulin-like growth factors (IGFs) system has been demonstrated to play an important role in stem cell biology to either promote proliferation and self-renewal or enhance differentiation onset and outcome, depending on the cell culture conditions. In this review, we will describe the importance of IGFs, IGF-1 and IGF-2, in development and in the MSC niche and how they affect the pluripotency or differentiation towards multiple lineages of the three germ layers. Twit Text FOAVip The Roles of Insulin-Like Growth Factors in Mesenchymal Stem Cell Niche ????Stem Cells Int http://www.kidney.de/pget.php?&tw=1&pmid=28298931 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28298931 #FOAvip English Wikipedia <ref>{{Cite pmid|28298931}}</ref> The Roles of Insulin-Like Growth Factors in Mesenchymal Stem Cell Niche #MMPMID28298931 Youssef A; Aboalola D; Han VKM Stem Cells Int 2017[]; 2017 (ä): ä PMID28298931show ga Many tissues contain adult mesenchymal stem cells (MSCs), which may be used in tissue regeneration therapies. However, the MSC availability in most tissues is limited which demands expansion in vitro following isolation. Like many developing cells, the state of MSCs is affected by the surrounding microenvironment, and mimicking this natural microenvironment that supports multipotent or differentiated state in vivo is essential to understand for the successful use of MSC in regenerative therapies. Many researchers are, therefore, optimizing cell culture conditions in vitro by altering growth factors, extracellular matrices, chemicals, oxygen tension, and surrounding pH to enhance stem cells self-renewal or differentiation. Insulin-like growth factors (IGFs) system has been demonstrated to play an important role in stem cell biology to either promote proliferation and self-renewal or enhance differentiation onset and outcome, depending on the cell culture conditions. In this review, we will describe the importance of IGFs, IGF-1 and IGF-2, in development and in the MSC niche and how they affect the pluripotency or differentiation towards multiple lineages of the three germ layers. äThe Roles of Insulin-Like Growth Factors in Mesenchymal Stem Cell Nich(epmc).pdf DeepDyve Pubget Overpricing