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10.5152/eurjrheum.2016.055

http://scihub22266oqcxt.onion/10.5152/eurjrheum.2016.055
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C5335892!5335892!28293458
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suck abstract from ncbi


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pmid28293458      Eur+J+Rheumatol 2017 ; 4 (1): 68-9
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  • The novel use of combined IL-1 and IL-6 inhibition in a patient with severe, aggressive, erosive, systemic-onset juvenile idiopathic arthritis #MMPMID28293458
  • Lee M; Isaacs J
  • Eur J Rheumatol 2017[Mar]; 4 (1): 68-9 PMID28293458show ga
  • Systemic-onset juvenile idiopathic arthritis (SoJIA) is a form of juvenile idiopathic arthritis (JIA) that typically presents with prominent systemic features and accounts for approximately 10?15% of children with JIA. Pro-inflammatory cytokine pathways are thought to be involved in its pathogenesis, including interleukin-1 (IL-1) and interleukin-6 (IL-6), and laboratory tests demonstrate a prominent inflammatory response with high CRP and ferritin levels. We present a case of severe, aggressive, erosive SoJIA in a 17-year-old male resistant to multiple biologic therapies treated with a novel combination of IL-1 and IL-6 blockade along with subcutaneous methotrexate.
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