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2017 ; 4
(1
): 68-69
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The novel use of combined IL-1 and IL-6 inhibition in a patient with severe,
aggressive, erosive, systemic-onset juvenile idiopathic arthritis
#MMPMID28293458
Lee M
; Isaacs J
Eur J Rheumatol
2017[Mar]; 4
(1
): 68-69
PMID28293458
show ga
Systemic-onset juvenile idiopathic arthritis (SoJIA) is a form of juvenile
idiopathic arthritis (JIA) that typically presents with prominent systemic
features and accounts for approximately 10-15% of children with JIA.
Pro-inflammatory cytokine pathways are thought to be involved in its
pathogenesis, including interleukin-1 (IL-1) and interleukin-6 (IL-6), and
laboratory tests demonstrate a prominent inflammatory response with high CRP and
ferritin levels. We present a case of severe, aggressive, erosive SoJIA in a
17-year-old male resistant to multiple biologic therapies treated with a novel
combination of IL-1 and IL-6 blockade along with subcutaneous methotrexate.