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10.1007/s10545-016-9988-z http://scihub22266oqcxt.onion/10.1007/s10545-016-9988-z C5335863!5335863 !27743312     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27743312 &cmd=llinks): Failed to open stream: HTTP request failed! 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Angiotensin receptor blockade mediated amelioration of mucopolysaccharidosis type I cardiac and craniofacial pathology |pdf=|usr=}}{{27743312 }} gab.com Text Angiotensin receptor blockade mediated amelioration of mucopolysaccharidosis type I cardiac and craniofacial pathology JO: J Inherit Metab Dis http://www.kidney.de/pget.php?&tw=1&pmid=27743312 #FOAvip Mucopolysaccharidosis type I (MPS IH) is a lysosomal storage disease (LSD) caused by inactivating mutations to the alpha-L-iduronidase (IDUA) gene. Treatment focuses on IDUA enzyme replacement and currently employed methods can be non-uniform in their efficacy particularly for the cardiac and craniofacial pathology. Therefore, we undertook efforts to better define the pathological cascade accounting for treatment refractory manifestations and demonstrate a role for the renin angiotensin system (RAS) using the IDUA(-/-) mouse model. Perturbation of the RAS in the aorta was more profound in male animals suggesting a causative role in the observed gender dimorphism and angiotensin receptor blockade (ARB) resulted in improved cardiac function. Further, we show the ability of losartan to prevent shortening of the snout, a common craniofacial anomaly in IDUA(-/-) mice. These data show a key role for the RAS in MPS associated pathology and support the inclusion of losartan as an augmentation to current therapies. Twit Text FOAVip Angiotensin receptor blockade mediated amelioration of mucopolysaccharidosis type I cardiac and craniofacial pathology ????J Inherit Metab Dis http://www.kidney.de/pget.php?&tw=1&pmid=27743312 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27743312 #FOAvip English Wikipedia <ref>{{Cite pmid|27743312 }}</ref> Angiotensin receptor blockade mediated amelioration of mucopolysaccharidosis type I cardiac and craniofacial pathology #MMPMID27743312 Osborn MJ ; Webber BR ; McElmurry RT ; Rudser KD ; DeFeo AP ; Muradian M ; Petryk A ; Hallgrimsson B ; Blazar BR ; Tolar J ; Braunlin EA J Inherit Metab Dis 2017[Mar]; 40 (2 ): 281-289 PMID27743312 show ga Mucopolysaccharidosis type I (MPS IH) is a lysosomal storage disease (LSD) caused by inactivating mutations to the alpha-L-iduronidase (IDUA) gene. Treatment focuses on IDUA enzyme replacement and currently employed methods can be non-uniform in their efficacy particularly for the cardiac and craniofacial pathology. Therefore, we undertook efforts to better define the pathological cascade accounting for treatment refractory manifestations and demonstrate a role for the renin angiotensin system (RAS) using the IDUA(-/-) mouse model. Perturbation of the RAS in the aorta was more profound in male animals suggesting a causative role in the observed gender dimorphism and angiotensin receptor blockade (ARB) resulted in improved cardiac function. Further, we show the ability of losartan to prevent shortening of the snout, a common craniofacial anomaly in IDUA(-/-) mice. These data show a key role for the RAS in MPS associated pathology and support the inclusion of losartan as an augmentation to current therapies. |Angiotensin Receptor Antagonists/*pharmacology [MESH] |Animals [MESH] |Craniofacial Abnormalities/drug therapy/genetics/*pathology [MESH] |Disease Models, Animal [MESH] |Female [MESH] |Heart Diseases/drug therapy/genetics/*pathology [MESH] |Iduronidase/genetics [MESH] |Losartan/pharmacology [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mucopolysaccharidosis I/*drug therapy/genetics/pathology [MESH] |Mutation/drug effects/genetics [MESH] |Receptors, Angiotensin/metabolism [MESH]Angiotensin receptor blockade mediated amelioration of mucopolysacchar(epmc).pdf DeepDyve Pubget Overpricing