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10.1038/srep43173 http://scihub22266oqcxt.onion/10.1038/srep43173 C5335718!5335718!28256591     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28256591|t=2017. Nicotinic acid inhibits glioma invasion by facilitating Snail1 degradation |pdf=|usr=}}{{28256591}} gab.com Text Nicotinic acid inhibits glioma invasion by facilitating Snail1 degradation JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28256591 #FOAvip Malignant glioma is a formidable disease that commonly leads to death, mainly due to the invasion of tumor cells into neighboring tissues. Therefore, inhibition of tumor cell invasion may provide an effective therapy for malignant glioma. Here we report that nicotinic acid (NA), an essential vitamin, inhibits glioma cell invasion in vitro and in vivo. Treatment of the U251 glioma cells with NA in vitro results in reduced invasion, which is accompanied by a loss of mesenchymal phenotype and an increase in cell-cell adhesion. At the molecular level, transcription of the adherens junction protein E-cadherin is upregulated, leading to accumulation of E-cadherin protein at the cell-cell boundary. This can be attributed to NA?s ability to facilitate the ubiquitination and degradation of Snail1, a transcription factor that represses E-cadherin expression. Similarly, NA transiently inhibits neural crest migration in Xenopus embryos in a Snail1-dependent manner, indicating that the mechanism of action for NA in cell migration is evolutionarily conserved. We further show that NA injection blocks the infiltration of tumor cells into the adjacent brain tissues and improves animal survival in a rat model of glioma. These results suggest that NA treatment may be developed into a potential therapy for malignant glioma. Twit Text FOAVip Nicotinic acid inhibits glioma invasion by facilitating Snail1 degradation ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28256591 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28256591 #FOAvip English Wikipedia <ref>{{Cite pmid|28256591}}</ref> Nicotinic acid inhibits glioma invasion by facilitating Snail1 degradation #MMPMID28256591 Li J; Qu J; Shi Y; Perfetto M; Ping Z; Christian L; Niu H; Mei S; Zhang Q; Yang X; Wei S Sci Rep 2017[]; 7 (ä): ä PMID28256591show ga Malignant glioma is a formidable disease that commonly leads to death, mainly due to the invasion of tumor cells into neighboring tissues. Therefore, inhibition of tumor cell invasion may provide an effective therapy for malignant glioma. Here we report that nicotinic acid (NA), an essential vitamin, inhibits glioma cell invasion in vitro and in vivo. Treatment of the U251 glioma cells with NA in vitro results in reduced invasion, which is accompanied by a loss of mesenchymal phenotype and an increase in cell-cell adhesion. At the molecular level, transcription of the adherens junction protein E-cadherin is upregulated, leading to accumulation of E-cadherin protein at the cell-cell boundary. This can be attributed to NA?s ability to facilitate the ubiquitination and degradation of Snail1, a transcription factor that represses E-cadherin expression. Similarly, NA transiently inhibits neural crest migration in Xenopus embryos in a Snail1-dependent manner, indicating that the mechanism of action for NA in cell migration is evolutionarily conserved. We further show that NA injection blocks the infiltration of tumor cells into the adjacent brain tissues and improves animal survival in a rat model of glioma. These results suggest that NA treatment may be developed into a potential therapy for malignant glioma. äNicotinic acid inhibits glioma invasion by facilitating Snail1 degrada(epmc).pdf DeepDyve Pubget Overpricing