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10.1186/s13017-017-0124-7 http://scihub22266oqcxt.onion/10.1186/s13017-017-0124-7 C5335497!5335497!28265298     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       World+J+Emerg+Surg 2017 ; 12 (ä): ä Nephropedia Template TP {{tp|p=28265298|t=2017. Safety and effectiveness of propranolol in severely burned patients: systematic review and meta-analysis |pdf=|usr=}}{{28265298}} gab.com Text Safety and effectiveness of propranolol in severely burned patients: systematic review and meta-analysis JO: World J Emerg Surg http://www.kidney.de/pget.php?&tw=1&pmid=28265298 #FOAvip Background: The objective of this systematic review was to determine the effectiveness and safety of propranolol compared to placebo or usual care for improving clinical relevant outcomes in severely burned patients (TBSA >20%). Methods: Relevant articles from randomized controlled trials were identified by a literature search in MEDLINE, EMBASE, and CENTRAL. We included trials involving patients with a severe burn (>20% of total body surface area affected). Trials were eligible if they evaluated propranolol and compared to usual care or placebo. Two investigators independently assessed articles for inclusion and exclusion criteria and selected studies for the final analysis. We conducted a meta-analysis using a random-effects model. Results: We included ten studies in our systematic review. These studies randomized a total of 1236 participants. There were no significant differences between propranolol and placebo with respect to mortality (RD ?0.02 [95% CI ?0.06 to 0.02]), sepsis (RD ?0.03 [95% CI ?0.09 to 0.04]), and the overall hospital stay (MD ?0.37 [?4.52 to 3.78]). Propranolol-treated adults had a decrease in requirements of blood transfusions (MD ?185.64 [95% CI ?331.06 to ?40.43]) and a decreased heart rate (MD ?26.85 [95% CI ?39.95 to ?13.75]). Conclusions: Our analysis indicates that there were no differences in mortality or sepsis in severely burned patients treated with propranolol compared with those who had usual care or placebo. However, the use of propranolol in these patients resulted in lower requirements of blood transfusion and lower values of heart rate. The evidence synthesized in this systematic review is limited to conclude that propranolol reduces the length of hospital stay among severely burned patients. Future trials should assess the impact of propranolol on clinically relevant outcomes such as mortality and adverse events. Electronic supplementary material: The online version of this article (doi:10.1186/s13017-017-0124-7) contains supplementary material, which is available to authorized users. Twit Text FOAVip Safety and effectiveness of propranolol in severely burned patients: systematic review and meta-analysis ????World J Emerg Surg http://www.kidney.de/pget.php?&tw=1&pmid=28265298 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28265298 #FOAvip English Wikipedia <ref>{{Cite pmid|28265298}}</ref> Safety and effectiveness of propranolol in severely burned patients: systematic review and meta-analysis #MMPMID28265298 Manzano-Nunez R; García-Perdomo HA; Ferrada P; Ordoñez Delgado CA; Gomez DA; Foianini JE World J Emerg Surg 2017[]; 12 (ä): ä PMID28265298show ga Background: The objective of this systematic review was to determine the effectiveness and safety of propranolol compared to placebo or usual care for improving clinical relevant outcomes in severely burned patients (TBSA >20%). Methods: Relevant articles from randomized controlled trials were identified by a literature search in MEDLINE, EMBASE, and CENTRAL. We included trials involving patients with a severe burn (>20% of total body surface area affected). Trials were eligible if they evaluated propranolol and compared to usual care or placebo. Two investigators independently assessed articles for inclusion and exclusion criteria and selected studies for the final analysis. We conducted a meta-analysis using a random-effects model. Results: We included ten studies in our systematic review. These studies randomized a total of 1236 participants. There were no significant differences between propranolol and placebo with respect to mortality (RD ?0.02 [95% CI ?0.06 to 0.02]), sepsis (RD ?0.03 [95% CI ?0.09 to 0.04]), and the overall hospital stay (MD ?0.37 [?4.52 to 3.78]). Propranolol-treated adults had a decrease in requirements of blood transfusions (MD ?185.64 [95% CI ?331.06 to ?40.43]) and a decreased heart rate (MD ?26.85 [95% CI ?39.95 to ?13.75]). Conclusions: Our analysis indicates that there were no differences in mortality or sepsis in severely burned patients treated with propranolol compared with those who had usual care or placebo. However, the use of propranolol in these patients resulted in lower requirements of blood transfusion and lower values of heart rate. The evidence synthesized in this systematic review is limited to conclude that propranolol reduces the length of hospital stay among severely burned patients. Future trials should assess the impact of propranolol on clinically relevant outcomes such as mortality and adverse events. Electronic supplementary material: The online version of this article (doi:10.1186/s13017-017-0124-7) contains supplementary material, which is available to authorized users. äSafety and effectiveness of propranolol in severely burned patients: s(epmc).pdf DeepDyve Pubget Overpricing