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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Pediatr+Crit+Care+Med 2017 ; 18 (3 Suppl 1): S4-S16 Nephropedia Template TP
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Epidemiology and outcomes of pediatric multiple organ dysfunction syndrome (MODS) #MMPMID28248829
Pediatr Crit Care Med 2017[Mar]; 18 (3 Suppl 1): S4-S16 PMID28248829show ga
Objective: To summarize the epidemiology and outcomes of children with multiple organ dysfunction syndrome (MODS), as part of the Eunice Kennedy Shriver National Institute of Child Health and Human Development MODS Workshop (March 26?27, 2015). Data Sources: Literature review, research data, and expert opinion Study Selection: Not applicable Data Extraction: Moderated by an experienced expert from the field, issues relevant to the epidemiology and outcomes of children with MODS were presented, discussed and debated with a focus on identifying knowledge gaps and research priorities. Data Synthesis: Summary of presentations and discussion supported and supplemented by relevant literature. Conclusions: A full understanding the epidemiology and outcome of MODS in children is limited by inconsistent definitions and populations studied. Nonetheless, pediatric MODS is common among PICU patients, occurring in up to 57% depending on the population studied; sepsis remains its leading cause. Pediatric MODS leads to considerable short-term morbidity and mortality. Long-term outcomes of MODS in children have not been well studied; however, studies of adults and children with other critical illnesses suggest that the risk of long-term adverse sequelae is high. Characterization of the long-term outcomes of pediatric MODS is crucial to identify opportunities for improved treatment and recovery strategies that will improve the quality of life of critically ill children and their families. The Workshop identified important knowledge gaps and research priorities intended to promote the development of standard definitions and the identification of modifiable factors related to its occurrence and outcome.