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10.1038/srep43719 http://scihub22266oqcxt.onion/10.1038/srep43719 C5334649!5334649 !28255175     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28255175 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Sci+Rep 2017 ; 7 (?): 43719 Nephropedia Template TP {{tp|p=28255175 |t=2017. Disruption of Endothelial Cell Homeostasis Plays a Key Role in the Early Pathogenesis of Coronary Artery Abnormalities in Kawasaki Disease |pdf=|usr=}}{{28255175 }} gab.com Text Disruption of Endothelial Cell Homeostasis Plays a Key Role in the Early Pathogenesis of Coronary Artery Abnormalities in Kawasaki Disease JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28255175 #FOAvip Disruption of endothelial cell homeostasis may be associated with the pathogenesis of coronary artery abnormalities (CAA) in Kawasaki disease (KD). We sought to clarify the poorly understood pathogenic role of endothelial cell survival and death in KD vasculitis. Human umbilical vein endothelial cells (HUVECs) stimulated with sera from KD patients, compared with sera from patients with bacterial infections, exhibited significant increases in cytotoxicity, high mobility group box protein 1 (HMGB-1), and caspase-3/7 and a decrease in phosphorylated Akt/Akt (pAkt/Akt) ratios. HUVECs stimulated with sera from KD patients treated with immunoglobulin (IG) showed significantly decreased cytotoxicity, HMGB-1, and caspase-3/7 levels and increased pAkt/Akt ratios, as compared with results for untreated HUVECs (P?<?0.001, P?=?0.008, P?=?0.040, and P?<?0.001, respectively). In HUVECs stimulated with sera from KD patients, the increased cytotoxicity levels and the suppression of increased pAkt/Akt ratios after subsequent IG treatment were closely related to the development of CAA (P?=?0.002 and P?=?0.035). Our data reveal that shifting the balance toward cell death rather than survival appears to perturb endothelial cell homeostasis and is closely related to the development of CAA. The cytoprotective effects of IG treatment appear to ameliorate endothelial cell homeostasis. Twit Text FOAVip Disruption of Endothelial Cell Homeostasis Plays a Key Role in the Early Pathogenesis of Coronary Artery Abnormalities in Kawasaki Disease ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28255175 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28255175 #FOAvip English Wikipedia <ref>{{Cite pmid|28255175 }}</ref> Disruption of Endothelial Cell Homeostasis Plays a Key Role in the Early Pathogenesis of Coronary Artery Abnormalities in Kawasaki Disease #MMPMID28255175 Ueno K ; Ninomiya Y ; Hazeki D ; Masuda K ; Nomura Y ; Kawano Y Sci Rep 2017[Mar]; 7 (?): 43719 PMID28255175 show ga Disruption of endothelial cell homeostasis may be associated with the pathogenesis of coronary artery abnormalities (CAA) in Kawasaki disease (KD). We sought to clarify the poorly understood pathogenic role of endothelial cell survival and death in KD vasculitis. Human umbilical vein endothelial cells (HUVECs) stimulated with sera from KD patients, compared with sera from patients with bacterial infections, exhibited significant increases in cytotoxicity, high mobility group box protein 1 (HMGB-1), and caspase-3/7 and a decrease in phosphorylated Akt/Akt (pAkt/Akt) ratios. HUVECs stimulated with sera from KD patients treated with immunoglobulin (IG) showed significantly decreased cytotoxicity, HMGB-1, and caspase-3/7 levels and increased pAkt/Akt ratios, as compared with results for untreated HUVECs (P? |Bacterial Infections/complications/diagnosis/microbiology [MESH] |Biomarkers [MESH] |Caspases/metabolism [MESH] |Child, Preschool [MESH] |Coronary Vessels/*metabolism/pathology [MESH] |Endothelial Cells/*metabolism [MESH] |Female [MESH] |Fluorescent Antibody Technique [MESH] |HMGB1 Protein/metabolism [MESH] |Homeostasis [MESH] |Human Umbilical Vein Endothelial Cells/metabolism [MESH] |Humans [MESH] |Infant [MESH] |Male [MESH] |Mucocutaneous Lymph Node Syndrome/diagnosis/*etiology/*metabolism [MESH] |Phosphorylation [MESH]Disruption of Endothelial Cell Homeostasis Plays a Key Role in the Ear(epmc).pdf DeepDyve Pubget Overpricing