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10.1111/acel.12572 http://scihub22266oqcxt.onion/10.1111/acel.12572 C5334533!5334533!28156052     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Aging+Cell 2017 ; 16 (2): 414-21 Nephropedia Template TP {{tp|p=28156052|t=2017. Melatonin alleviates lipopolysaccharide?compromised integrity of blood?brain barrier through activating AMP?activated protein kinase in old mice |pdf=|usr=}}{{28156052}} gab.com Text Melatonin alleviates lipopolysaccharide compromised integrity of blood brain barrier through activating AMP activated protein kinase in old mice JO: Aging Cell http://www.kidney.de/pget.php?&tw=1&pmid=28156052 #FOAvip Blood?brain barrier (BBB) dysfunction is considered to be an early event in the pathogenesis of a variety of neurological diseases in old patients, and this could occur in old people even when facing common stress. However, the mechanism remains to be defined. In this study, we tested the hypothesis that decreased melatonin levels may account for the BBB disruption in old mice challenged with lipopolysaccharide (LPS), which mimicked the common stress of sepsis. Mice (24?28 months of age) received melatonin (10 mg kg?1 day?1, intraperitoneally, i.p.) or saline for one week before exposing to LPS (1 mg kg?1, i.p.). Evan's blue dye (EB) and immunoglobulin G (IgG) leakage were used to assess BBB permeability. Immunostaining and Western blot were used to detect protein expression and distribution. Our results showed that LPS significantly increased BBB permeability in old mice accompanied by the degradation of tight junction proteins occludin and claudin?5, suppressed AMP?activated protein kinase (AMPK) activation, and elevated gp91phox protein expression. Interestingly, administration of melatonin for one week significantly decreased LPS?induced BBB disruption, AMPK suppression, and gp91phox upregualtion. Moreover, activation of AMPK with metformin significantly inhibited LPS?induced gp91phox upregualtion in endothelial cells. Taken together, our findings demonstrate that melatonin alleviates LPS?induced BBB disruption through activating AMPK and inhibiting gp91phox upregulation in old mice. Twit Text FOAVip Melatonin alleviates lipopolysaccharide compromised integrity of blood brain barrier through activating AMP activated protein kinase in old mice ????Aging Cell http://www.kidney.de/pget.php?&tw=1&pmid=28156052 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28156052 #FOAvip English Wikipedia <ref>{{Cite pmid|28156052}}</ref> Melatonin alleviates lipopolysaccharide?compromised integrity of blood?brain barrier through activating AMP?activated protein kinase in old mice #MMPMID28156052 Wang X; Xue G; Liu W; Shu H; Wang M; Sun Y; Liu X; Sun YE; Liu C; Liu J; Liu W; Jin X Aging Cell 2017[Apr]; 16 (2): 414-21 PMID28156052show ga Blood?brain barrier (BBB) dysfunction is considered to be an early event in the pathogenesis of a variety of neurological diseases in old patients, and this could occur in old people even when facing common stress. However, the mechanism remains to be defined. In this study, we tested the hypothesis that decreased melatonin levels may account for the BBB disruption in old mice challenged with lipopolysaccharide (LPS), which mimicked the common stress of sepsis. Mice (24?28 months of age) received melatonin (10 mg kg?1 day?1, intraperitoneally, i.p.) or saline for one week before exposing to LPS (1 mg kg?1, i.p.). Evan's blue dye (EB) and immunoglobulin G (IgG) leakage were used to assess BBB permeability. Immunostaining and Western blot were used to detect protein expression and distribution. Our results showed that LPS significantly increased BBB permeability in old mice accompanied by the degradation of tight junction proteins occludin and claudin?5, suppressed AMP?activated protein kinase (AMPK) activation, and elevated gp91phox protein expression. Interestingly, administration of melatonin for one week significantly decreased LPS?induced BBB disruption, AMPK suppression, and gp91phox upregualtion. Moreover, activation of AMPK with metformin significantly inhibited LPS?induced gp91phox upregualtion in endothelial cells. Taken together, our findings demonstrate that melatonin alleviates LPS?induced BBB disruption through activating AMPK and inhibiting gp91phox upregulation in old mice. äMelatonin alleviates lipopolysaccharide?compromised integrity of blood(epmc).pdf DeepDyve Pubget Overpricing