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2017 ; 56
(2
): 461-482
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English Wikipedia
Fruitflow(®): the first European Food Safety Authority-approved natural
cardio-protective functional ingredient
#MMPMID27388464
O'Kennedy N
; Raederstorff D
; Duttaroy AK
Eur J Nutr
2017[Mar]; 56
(2
): 461-482
PMID27388464
show ga
Hyperactive platelets, in addition to their roles in thrombosis, are also
important mediators of atherogenesis. Antiplatelet drugs are not suitable for use
where risk of a cardiovascular event is relatively low. It is therefore important
to find alternative safe antiplatelet inhibitors for the vulnerable population
who has hyperactive platelets in order to reduce the risk of cardiovascular
disease. Potent antiplatelet factors were identified in water-soluble tomato
extract (Fruitflow(®)), which significantly inhibited platelet aggregation. Human
volunteer studies demonstrated the potency and bioavailability of active
compounds in Fruitflow(®). Fruitflow(®) became the first product in Europe to
obtain an approved, proprietary health claim under Article 13(5) of the European
Health Claims Regulation 1924/2006 on nutrition and health claims made on foods.
Fruitflow(®) is now commercially available in different countries worldwide. In
addition to its reduction in platelet reactivity, Fruitflow(®) contains
anti-angiotensin-converting enzyme and anti-inflammatory factors, making it an
effective and natural cardio-protective functional food.
|*Food Safety
[MESH]
|*Functional Food
[MESH]
|*Platelet Aggregation Inhibitors
[MESH]
|Angiotensin-Converting Enzyme Inhibitors
[MESH]
|Anti-Inflammatory Agents
[MESH]
|Atherosclerosis/epidemiology/prevention & control
[MESH]
|Blood Platelets/physiology
[MESH]
|Cardiotonic Agents
[MESH]
|Cardiovascular Diseases/epidemiology/etiology/*prevention & control
[MESH]