Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28207203
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Is chronic kidney disease an adverse factor in lung cancer clinical outcome? A
propensity score matching study
#MMPMID28207203
Lu MS
; Chen MF
; Lin CC
; Tseng YH
; Huang YK
; Liu HP
; Tsai YH
Thorac Cancer
2017[Mar]; 8
(2
): 106-113
PMID28207203
show ga
BACKGROUND: Comorbidity has a great impact on lung cancer survival. Renal
function status may affect treatment decisions and drug toxicity. The survival
outcome in lung cancer patients with coexisting chronic kidney disease (CKD) has
not been fully evaluated. We hypothesized that CKD is an independent risk factor
for mortality in patients with lung cancer. METHODS: A retrospective,
propensity-matched study of 434 patients diagnosed between June 2004 and May 2012
was conducted. CKD was defined as estimated glomerular filtration rate
<60?mL/minute. Lung cancer and coexisting CKD patients were matched 1:1 to
patients with lung cancer without CKD. RESULTS: Age, gender, smoking status,
histology, and lung cancer stage were not statistically significantly different
between the CKD and non-CKD groups. Kaplan-Meier survival analysis demonstrated a
median survival of 7.26?months (95% confidence interval [CI] 6.06-8.46) in the
CKD group compared with 7.82?months (95% CI 6.33-9.30) in the non-CKD group
(P?=?0.41). Lung cancer stage-specific survival is not affected by CKD. Although
lung cancer patients with CKD presented with an increased risk of death of 6%,
this result was not statistically significant (hazard ratio 1.06, 95% CI
0.93-1.22; P?=?0.41). CONCLUSION: According to our limited experience, CKD is not
an independent risk factor for survival in lung cancer patients. Clinicians
should not be discouraged to treat lung cancer patients with CKD.
free
free
free
