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10.1101/cshperspect.a027128 http://scihub22266oqcxt.onion/10.1101/cshperspect.a027128 C5334246!5334246!28062556     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28062556&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Cold+Spring+Harb+Perspect+Med 2017 ; 7 (3): ä Nephropedia Template TP {{tp|p=28062556|t=2017. The Cellular Origin and Evolution of Breast Cancer |pdf=|usr=}}{{28062556}} gab.com Text The Cellular Origin and Evolution of Breast Cancer JO: Cold Spring Harb Perspect Med http://www.kidney.de/pget.php?&tw=1&pmid=28062556 #FOAvip In this review, we will discuss how the cell of origin may modulate breast cancer intratumoral heterogeneity (ITH) as well as the role of ITH in the evolution of cancer. The clonal evolution and the cancer stem cell (CSC) models, as well as a model that integrates clonal evolution with a CSC hierarchy, have all been proposed to explain the development of ITH. The extent of ITH correlates with clinical outcome and reflects the cellular complexity and dynamics within a tumor. A unique subtype of breast cancer, the claudin-low subtype that is highly resistant to chemotherapy and most closely resembles mammary epithelial stem cells, will be discussed. Furthermore, we will review how the interactions among various tumor cells, some with distinct mutations, may impact breast cancer treatment. Finally, novel technologies that may help advance our understanding of ITH and lead to improvements in the design of new treatments also will be discussed. Twit Text FOAVip The Cellular Origin and Evolution of Breast Cancer ????Cold Spring Harb Perspect Med http://www.kidney.de/pget.php?&tw=1&pmid=28062556 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28062556 #FOAvip English Wikipedia <ref>{{Cite pmid|28062556}}</ref> The Cellular Origin and Evolution of Breast Cancer #MMPMID28062556 Zhang M; Lee AV; Rosen JM Cold Spring Harb Perspect Med 2017[Mar]; 7 (3): ä PMID28062556show ga In this review, we will discuss how the cell of origin may modulate breast cancer intratumoral heterogeneity (ITH) as well as the role of ITH in the evolution of cancer. The clonal evolution and the cancer stem cell (CSC) models, as well as a model that integrates clonal evolution with a CSC hierarchy, have all been proposed to explain the development of ITH. The extent of ITH correlates with clinical outcome and reflects the cellular complexity and dynamics within a tumor. A unique subtype of breast cancer, the claudin-low subtype that is highly resistant to chemotherapy and most closely resembles mammary epithelial stem cells, will be discussed. Furthermore, we will review how the interactions among various tumor cells, some with distinct mutations, may impact breast cancer treatment. Finally, novel technologies that may help advance our understanding of ITH and lead to improvements in the design of new treatments also will be discussed. äThe Cellular Origin and Evolution of Breast Cancer (epmc).pdf DeepDyve Pubget Overpricing