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2017 ; 13
(1
): 1-12
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Nucleotides and nucleoside signaling in the regulation of the epithelium to
mesenchymal transition (EMT)
#MMPMID27900516
Martínez-Ramírez AS
; Díaz-Muñoz M
; Butanda-Ochoa A
; Vázquez-Cuevas FG
Purinergic Signal
2017[Mar]; 13
(1
): 1-12
PMID27900516
show ga
The epithelium-mesenchymal transition (EMT) is an important process of cell
plasticity, consisting in the loss of epithelial identity and the gain of
mesenchymal characteristics through the coordinated activity of a highly
regulated informational program. Although it was originally described in the
embryonic development, an important body of information supports its role in
pathology, mainly in cancerous and fibrotic processes. The purinergic system of
inter-cellular communication, mainly based in ATP and adenosine acting throughout
their specific receptors, has emerged as a potent regulator of the EMT in several
pathological entities. In this context, cellular signaling associated to purines
is opening the understanding of a new element in the complex regulatory network
of this phenotypical differentiation process. In this review, we have summarized
recent information about the role of ATP and adenosine in EMT, as a growing field
with high therapeutic potential.