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2017 ; 32
(4
): 672-678
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Bacterial Species and Antibiotic Sensitivity in Korean Patients Diagnosed with
Acute Otitis Media and Otitis Media with Effusion
#MMPMID28244296
Kim SH
; Jeon EJ
; Hong SM
; Bae CH
; Lee HY
; Park MK
; Byun JY
; Kim MG
; Yeo SG
J Korean Med Sci
2017[Apr]; 32
(4
): 672-678
PMID28244296
show ga
Changes over time in pathogens and their antibiotic sensitivity resulting from
the recent overuse and misuse of antibiotics in otitis media (OM) have
complicated treatment. This study evaluated changes over 5 years in principal
pathogens and their antibiotic sensitivity in patients in Korea diagnosed with
acute OM (AOM) and OM with effusion (OME). The study population consisted of 683
patients who visited the outpatient department of otorhinolaryngology in 7
tertiary hospitals in Korea between January 2010 and May 2015 and were diagnosed
with acute AOM or OME. Aural discharge or middle ear fluid were collected from
patients in the operating room or outpatient department and subjected to tests of
bacterial identification and antibiotic sensitivity. The overall bacteria
detection rate of AOM was 62.3% and OME was 40.9%. The most frequently isolated
Gram-positive bacterial species was coagulase negative Staphylococcus aureus
(CNS) followed by methicillin-susceptible S. aureus (MSSA), methicillin-resistant
S. aureus (MRSA), and Streptococcus pneumonia (SP), whereas the most frequently
isolated Gram-negative bacterium was Pseudomonas aeruginosa (PA). Regardless of
OM subtype, ? 80% of CNS and MRSA strains were resistant to penicillin (PC) and
tetracycline (TC); isolated MRSA strains showed low sensitivity to other
antibiotics, with 100% resistant to PC, TC, cefoxitin (CFT), and erythromycin
(EM); and isolated PA showed low sensitivity to quinolone antibiotics, including
ciprofloxacin (CIP) and levofloxacin (LFX), and to aminoglycosides. Bacterial
species and antibiotic sensitivity did not change significantly over 5 years. The
rate of detection of MRSA was higher in OME than in previous studies. As
bacterial predominance and antibiotic sensitivity could change over time,
continuous and periodic surveillance is necessary in guiding appropriate
antibacterial therapy.