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10.4084/MJHID.2017.015

http://scihub22266oqcxt.onion/10.4084/MJHID.2017.015
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C5333733!5333733!28293403
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suck abstract from ncbi


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pmid28293403      Mediterr+J+Hematol+Infect+Dis 2017 ; 9 (1): ä
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  • Hydroxycarbamine: from an Old Drug Used in Malignant Hemopathies to a Current Standard in Sickle Cell Disease #MMPMID28293403
  • Cannas G; Poutrel S; Thomas X
  • Mediterr J Hematol Infect Dis 2017[]; 9 (1): ä PMID28293403show ga
  • While hydroxycarbamide (hydroxyurea, HU) has less and fewer indications in malignant hemopathies, it represents the only widely used drug which modifies sickle cell disease pathogenesis. Clinical experience with HU for patients with sickle cell disease has been accumulated over the past 25 years in Western countries. The review of the literature provides increasing support for safety and efficacy in both children and adults for reducing acute vaso-occlusive events including pain episodes and acute chest syndrome. No increased incidence of leukemia and teratogenicity was demonstrated. HU has become the standard-of-care for sickle cell anemia but remains underused. Barriers to its use should be identified and overcome.
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