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10.1038/srep43614 http://scihub22266oqcxt.onion/10.1038/srep43614 C5333621!5333621!28252667     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28252667&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28252667|t=2017. Effects of multiple genetic loci on the pathogenesis from serum urate to gout |pdf=|usr=}}{{28252667}} gab.com Text Effects of multiple genetic loci on the pathogenesis from serum urate to gout JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28252667 #FOAvip Gout is a common arthritis resulting from increased serum urate, and many loci have been identified that are associated with serum urate and gout. However, their influence on the progression from elevated serum urate levels to gout is unclear. This study aims to explore systematically the effects of genetic variants on the pathogenesis in approximately 5,000 Chinese individuals. Six genes (PDZK1, GCKR, TRIM46, HNF4G, SLC17A1, LRRC16A) were determined to be associated with serum urate (PFDR?<?0.05) in the Chinese population for the first time. ABCG2 and a novel gene, SLC17A4, contributed to the development of gout from hyperuricemia (OR?=?1.56, PFDR?=?3.68E-09; OR?=?1.27, PFDR?=?0.013, respectively). Also, HNF4G is a novel gene associated with susceptibility to gout (OR?=?1.28, PFDR?=?1.08E-03). In addition, A1CF and TRIM46 were identified as associated with gout in the Chinese population for the first time (PFDR?<?0.05). The present study systematically determined genetic effects on the progression from elevated serum urate to gout and suggests that urate-associated genes functioning as urate transporters may play a specific role in the pathogenesis of gout. Furthermore, two novel gout-associated genes (HNF4G and SLC17A4) were identified. Twit Text FOAVip Effects of multiple genetic loci on the pathogenesis from serum urate to gout ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28252667 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28252667 #FOAvip English Wikipedia <ref>{{Cite pmid|28252667}}</ref> Effects of multiple genetic loci on the pathogenesis from serum urate to gout #MMPMID28252667 Dong Z; Zhou J; Jiang S; Li Y; Zhao D; Yang C; Ma Y; Wang Y; He H; Ji H; Yang Y; Wang X; Xu X; Pang Y; Zou H; Jin L; Wang J Sci Rep 2017[]; 7 (ä): ä PMID28252667show ga Gout is a common arthritis resulting from increased serum urate, and many loci have been identified that are associated with serum urate and gout. However, their influence on the progression from elevated serum urate levels to gout is unclear. This study aims to explore systematically the effects of genetic variants on the pathogenesis in approximately 5,000 Chinese individuals. Six genes (PDZK1, GCKR, TRIM46, HNF4G, SLC17A1, LRRC16A) were determined to be associated with serum urate (PFDR? äEffects of multiple genetic loci on the pathogenesis from serum urate (epmc).pdf DeepDyve Pubget Overpricing