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10.1212/WNL.0000000000003690 http://scihub22266oqcxt.onion/10.1212/WNL.0000000000003690 C5333514!5333514!28179470     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28179470&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neurology 2017 ; 88 (10): 938-43 Nephropedia Template TP {{tp|p=28179470|t=2017. Phase I/II multicenter ketogenic diet study for adult superrefractory status epilepticus |pdf=|usr=}}{{28179470}} gab.com Text Phase I/II multicenter ketogenic diet study for adult superrefractory status epilepticus JO: Neurology http://www.kidney.de/pget.php?&tw=1&pmid=28179470 #FOAvip Objective:: To investigate the feasibility, safety, and efficacy of a ketogenic diet (KD) for superrefractory status epilepticus (SRSE) in adults. Methods:: We performed a prospective multicenter study of patients 18 to 80 years of age with SRSE treated with a KD treatment algorithm. The primary outcome measure was significant urine and serum ketone body production as a biomarker of feasibility. Secondary measures included resolution of SRSE, disposition at discharge, KD-related side effects, and long-term outcomes. Results:: Twenty-four adults were screened for participation at 5 medical centers, and 15 were enrolled and treated with a classic KD via gastrostomy tube for SRSE. Median age was 47 years (interquartile range [IQR] 30 years), and 5 (33%) were male. Median number of antiseizure drugs used before KD was 8 (IQR 7), and median duration of SRSE before KD initiation was 10 days (IQR 7 days). KD treatment delays resulted from intravenous propofol use, ileus, and initial care received at a nonparticipating center. All patients achieved ketosis in a median of 2 days (IQR 1 day) on KD. Fourteen patients completed KD treatment, and SRSE resolved in 11 (79%; 73% of all patients enrolled). Side effects included metabolic acidosis, hyperlipidemia, constipation, hypoglycemia, hyponatremia, and weight loss. Five patients (33%) ultimately died. Conclusions:: KD is feasible in adults with SRSE and may be safe and effective. Comparative safety and efficacy must be established with randomized placebo-controlled trials. Classification of evidence:: This study provides Class IV evidence that in adults with SRSE, a KD is effective in inducing ketosis. Twit Text FOAVip Phase I/II multicenter ketogenic diet study for adult superrefractory status epilepticus ????Neurology http://www.kidney.de/pget.php?&tw=1&pmid=28179470 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28179470 #FOAvip English Wikipedia <ref>{{Cite pmid|28179470}}</ref> Phase I/II multicenter ketogenic diet study for adult superrefractory status epilepticus #MMPMID28179470 Cervenka MC; Hocker S; Koenig M; Bar B; Henry-Barron B; Kossoff EH; Hartman AL; Probasco JC; Benavides DR; Venkatesan A; Hagen EC; Dittrich D; Stern T; Radzik B; Depew M; Caserta FM; Nyquist P; Kaplan PW; Geocadin RG Neurology 2017[Mar]; 88 (10): 938-43 PMID28179470show ga Objective:: To investigate the feasibility, safety, and efficacy of a ketogenic diet (KD) for superrefractory status epilepticus (SRSE) in adults. Methods:: We performed a prospective multicenter study of patients 18 to 80 years of age with SRSE treated with a KD treatment algorithm. The primary outcome measure was significant urine and serum ketone body production as a biomarker of feasibility. Secondary measures included resolution of SRSE, disposition at discharge, KD-related side effects, and long-term outcomes. Results:: Twenty-four adults were screened for participation at 5 medical centers, and 15 were enrolled and treated with a classic KD via gastrostomy tube for SRSE. Median age was 47 years (interquartile range [IQR] 30 years), and 5 (33%) were male. Median number of antiseizure drugs used before KD was 8 (IQR 7), and median duration of SRSE before KD initiation was 10 days (IQR 7 days). KD treatment delays resulted from intravenous propofol use, ileus, and initial care received at a nonparticipating center. All patients achieved ketosis in a median of 2 days (IQR 1 day) on KD. Fourteen patients completed KD treatment, and SRSE resolved in 11 (79%; 73% of all patients enrolled). Side effects included metabolic acidosis, hyperlipidemia, constipation, hypoglycemia, hyponatremia, and weight loss. Five patients (33%) ultimately died. Conclusions:: KD is feasible in adults with SRSE and may be safe and effective. Comparative safety and efficacy must be established with randomized placebo-controlled trials. Classification of evidence:: This study provides Class IV evidence that in adults with SRSE, a KD is effective in inducing ketosis. äPhase I/II multicenter ketogenic diet study for adult superrefractory (epmc).pdf DeepDyve Pubget Overpricing