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Characteristics and outcomes in children with undifferentiated embryonal sarcoma of the liver: A report from the National Cancer Database #MMPMID27781381
Shi Y; Rojas Y; Zhang W; Beierle EA; Doski JJ; Goldfarb M; Goldin AB; Gow KW; Langer M; Meyers RL; Nuchtern JG; Vasudevan SA
Pediatr Blood Cancer 2017[Apr]; 64 (4): ä PMID27781381show ga
Objective: To examine patient characteristics and outcomes in children with undifferentiated embryonal sarcoma of the liver (UESL) using a multi?institutional database. Summary Background Data: UESL is a rare disease (incidence is one per million). Therefore, the current literature is mostly limited to small case series. Methods: The National Cancer Database was queried for primary UESL diagnosed between 1998 and 2012. Results: A total of 103 patients (<18 years) were identified. The 5?year overall survival of the entire group was 86%. The best outcomes were seen in children who had tumors smaller than 15 cm and were able to undergo surgical resection with or without chemotherapy. Margin status did not appear to significantly affect survival. The most common type of resection was hemihepatectomy (37%), followed by sectionectomy (10%) and trisectionectomy (10%). Orthotopic liver transplant was performed in 10 children, all of whom survived to 5 years. Conclusion: Surgical resection with or without chemotherapy should be the mainstay of treatment in children with UESL, and is associated with very favorable outcomes. Negative surgical margins were not associated with improved survival. Orthotopic liver transplantation may be a viable method of attaining local control in tumors, which would otherwise be unresectable.