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2017 ; 23
(ä): 6
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The cardiovascular risk factors associated with the plaque pattern on coronary
computed tomographic angiography in subjects for health check-up
#MMPMID28265463
Lee DH
; Youn HJ
; Jung HO
; Chang K
; Choi YS
; Jung JI
Clin Hypertens
2017[]; 23
(ä): 6
PMID28265463
show ga
BACKGROUND: Although it is known that coronary computed tomographic angiography
(CCTA) offers highly negative predictive value to exclude obstructive coronary
lesions, the plaque pattern on CCTA has not been fully understood. The purpose of
this study was to explore the difference of the plaque patterns on CCTA and to
assess the cardiovascular risks in healthy subjects. METHODS: A total of 3914
subjects (mean age: 55?±?10 years, M : F?=?2649 : 1265) who underwent CCTA for
health check-up between January 2009 and December 2012 were enrolled. According
to coronary artery calcium score (CACS) and plaque pattern on CCTA, subjects were
categorized into four groups (group 1: normal; group 2: "non-calcified" plaque;
group 3: "calcified" plaque; group 4: mixed plaque). We analyzed cardiovascular
risks and Framingham risk score (FRS) among the groups. RESULTS: The incidence of
each group was group 1 in 55.0% (2152/3914), group 2 in 5.1% (200/3914), group 3
in 8.2% (319/3914), and group 4 in 7.2% (280/3914), respectively. There was no
difference of FRS among the groups (6.4?±?6.4%; 6.5?±?4.6%; 8.2?±?5.8%;
7.7?±?5.7% p?=?0.086). In multivariate analysis, HbA1c (OR?=?2.285; 95%CI?=?1.029
- 5.071; p?=?0.042) in group 2; age (OR?=?1.115; 95%CI?=?1.034 - 1.202;
p?=?0.005) and smoking status (OR?=?3.386; 95%CI?=?1.124 - 10.202; p?=?0.030) in
group 3; and age (OR?=?1.054; 95%CI?=?1.011 - 1.099; p?=?0.014) and hypertension
(OR?=?3.087; 95%CI?=?1.536 - 6.202; p?=?0.001) in group 4 were independent
factors. CONCLUSIONS: Our data suggest that more individualized therapy for
reduction of cardiovascular risks associated with plaque pattern on CCTA could be
considered in healthy subjects.