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Hypothesis-Free Search for Connections between Birth Month and Disease Prevalence
in Large, Geographically Varied Cohorts
#MMPMID28269826
Borsi JP
AMIA Annu Symp Proc
2016[]; 2016
(?): 319-325
PMID28269826
show ga
We have sought to replicate and extend the Season-wide Association Study (SeaWAS)
of Boland, et al.(1) in identifying birth month-disease associations from
electronic health records (EHRs). We used methodology similar to that implemented
by Boland on three geographically distinct cohorts, for a total of 11.8 million
individuals derived from multiple data sources. We were able to identify eleven
out of sixteen literature-supported birth month associations as compared to seven
of sixteen for SeaWAS. Of the nine novel cardiovascular birth month associations
discovered by SeaWAS, we were able to replicate four. None of the novel
non-cardiovascular associations discovered by SeaWAS emerged as significant
relations in our study. We identified thirty birth month disease associations not
previously reported; of those, only six associations were validated in more than
one cohort. These results suggest that differences in cohort composition and
location can cause consequential variation in results of hypothesis-free
searches.