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10.1038/ncomms14605 http://scihub22266oqcxt.onion/10.1038/ncomms14605 C5333124!5333124!28233779     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28233779|t=2017. The role of alternative polyadenylation in the antiviral innate immune response |pdf=|usr=}}{{28233779}} gab.com Text The role of alternative polyadenylation in the antiviral innate immune response JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28233779 #FOAvip Alternative polyadenylation (APA) is an important regulatory mechanism of gene functions in many biological processes. However, the extent of 3? UTR variation and the function of APA during the innate antiviral immune response are unclear. Here, we show genome-wide poly(A) sites switch and average 3? UTR length shortens gradually in response to vesicular stomatitis virus (VSV) infection in macrophages. Genes with APA and mRNA abundance change are enriched in immune-related categories such as the Toll-like receptor, RIG-I-like receptor, JAK-STAT and apoptosis-related signalling pathways. The expression of 3? processing factors is down-regulated upon VSV infection. When the core 3? processing factors are knocked down, viral replication is affected. Thus, our study reports the annotation of genes with APA in antiviral immunity and highlights the roles of 3? processing factors on 3? UTR variation upon viral infection. Twit Text FOAVip The role of alternative polyadenylation in the antiviral innate immune response ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28233779 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28233779 #FOAvip English Wikipedia <ref>{{Cite pmid|28233779}}</ref> The role of alternative polyadenylation in the antiviral innate immune response #MMPMID28233779 Jia X; Yuan S; Wang Y; Fu Y; Ge Y; Ge Y; Lan X; Feng Y; Qiu F; Li P; Chen S; Xu A Nat Commun 2017[]; 8 (ä): ä PMID28233779show ga Alternative polyadenylation (APA) is an important regulatory mechanism of gene functions in many biological processes. However, the extent of 3? UTR variation and the function of APA during the innate antiviral immune response are unclear. Here, we show genome-wide poly(A) sites switch and average 3? UTR length shortens gradually in response to vesicular stomatitis virus (VSV) infection in macrophages. Genes with APA and mRNA abundance change are enriched in immune-related categories such as the Toll-like receptor, RIG-I-like receptor, JAK-STAT and apoptosis-related signalling pathways. The expression of 3? processing factors is down-regulated upon VSV infection. When the core 3? processing factors are knocked down, viral replication is affected. Thus, our study reports the annotation of genes with APA in antiviral immunity and highlights the roles of 3? processing factors on 3? UTR variation upon viral infection. äThe role of alternative polyadenylation in the antiviral innate immune(epmc).pdf DeepDyve Pubget Overpricing