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10.1038/srep43729 http://scihub22266oqcxt.onion/10.1038/srep43729 C5333092!5333092!28252046     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28252046|t=2017. Depletion of Gangliosides Enhances Articular Cartilage Repair in Mice |pdf=|usr=}}{{28252046}} gab.com Text Depletion of Gangliosides Enhances Articular Cartilage Repair in Mice JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28252046 #FOAvip Elucidation of the healing mechanisms in damaged tissues is a critical step for establishing breakthroughs in tissue engineering. Articular cartilage is clinically one of the most successful tissues to be repaired with regenerative medicine because of its homogeneous extracellular matrix and few cell types. However, we only poorly understand cartilage repair mechanisms, and hence, regenerated cartilage remains inferior to the native tissues. Here, we show that glycosylation is an important process for hypertrophic differentiation during articular cartilage repair. GM3, which is a precursor molecule for most gangliosides, was transiently expressed in surrounding damaged tissue, and depletion of GM3 synthase enhanced cartilage repair. Gangliosides also regulated chondrocyte hypertrophy via the Indian hedgehog pathway. These results identify a novel mechanism of cartilage healing through chondrocyte hypertrophy that is regulated by glycosylation. Manipulation of gangliosides and their synthases may have beneficial effects on articular cartilage repair. Twit Text FOAVip Depletion of Gangliosides Enhances Articular Cartilage Repair in Mice ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28252046 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28252046 #FOAvip English Wikipedia <ref>{{Cite pmid|28252046}}</ref> Depletion of Gangliosides Enhances Articular Cartilage Repair in Mice #MMPMID28252046 Matsuoka M; Onodera T; Homan K; Sasazawa F; Furukawa Ji; Momma D; Baba R; Hontani K; Joutoku Z; Matsubara S; Yamashita T; Iwasaki N Sci Rep 2017[]; 7 (ä): ä PMID28252046show ga Elucidation of the healing mechanisms in damaged tissues is a critical step for establishing breakthroughs in tissue engineering. Articular cartilage is clinically one of the most successful tissues to be repaired with regenerative medicine because of its homogeneous extracellular matrix and few cell types. However, we only poorly understand cartilage repair mechanisms, and hence, regenerated cartilage remains inferior to the native tissues. Here, we show that glycosylation is an important process for hypertrophic differentiation during articular cartilage repair. GM3, which is a precursor molecule for most gangliosides, was transiently expressed in surrounding damaged tissue, and depletion of GM3 synthase enhanced cartilage repair. Gangliosides also regulated chondrocyte hypertrophy via the Indian hedgehog pathway. These results identify a novel mechanism of cartilage healing through chondrocyte hypertrophy that is regulated by glycosylation. Manipulation of gangliosides and their synthases may have beneficial effects on articular cartilage repair. äDepletion of Gangliosides Enhances Articular Cartilage Repair in Mice (epmc).pdf DeepDyve Pubget Overpricing