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10.3390/genes8020066 http://scihub22266oqcxt.onion/10.3390/genes8020066 C5333055!5333055!28208785     free     free     free       Genes+(Basel) 2017 ; 8 (2): ä Nephropedia Template TP {{tp|p=28208785|t=2017. Dynamics of p53: A Master Decider of Cell Fate |pdf=|usr=}}{{28208785}} gab.com Text Dynamics of p53: A Master Decider of Cell Fate JO: Genes (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=28208785 #FOAvip Cellular stress-induced temporal alterations?i.e., dynamics?are typically exemplified by the dynamics of p53 that serve as a master to determine cell fate. p53 dynamics were initially identified as the variations of p53 protein levels. However, a growing number of studies have shown that p53 dynamics are also manifested in variations in the activity, spatial location, and posttranslational modifications of p53 proteins, as well as the interplay among all p53 dynamical features. These are essential in determining a specific outcome of cell fate. In this review, we discuss the importance of the multifaceted features of p53 dynamics and their roles in the cell fate decision process, as well as their potential applications in p53-based cancer therapy. The review provides new insights into p53 signaling pathways and their potentials in the development of new strategies in p53-based cancer therapy. Twit Text FOAVip Dynamics of p53: A Master Decider of Cell Fate ????Genes (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=28208785 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28208785 #FOAvip English Wikipedia <ref>{{Cite pmid|28208785}}</ref> Dynamics of p53: A Master Decider of Cell Fate #MMPMID28208785 Luo Q; Beaver JM; Liu Y; Zhang Z Genes (Basel) 2017[Feb]; 8 (2): ä PMID28208785show ga Cellular stress-induced temporal alterations?i.e., dynamics?are typically exemplified by the dynamics of p53 that serve as a master to determine cell fate. p53 dynamics were initially identified as the variations of p53 protein levels. However, a growing number of studies have shown that p53 dynamics are also manifested in variations in the activity, spatial location, and posttranslational modifications of p53 proteins, as well as the interplay among all p53 dynamical features. These are essential in determining a specific outcome of cell fate. In this review, we discuss the importance of the multifaceted features of p53 dynamics and their roles in the cell fate decision process, as well as their potential applications in p53-based cancer therapy. The review provides new insights into p53 signaling pathways and their potentials in the development of new strategies in p53-based cancer therapy. äDynamics of p53: A Master Decider of Cell Fate (epmc).pdf DeepDyve Pubget Overpricing