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10.3390/genes8020064 http://scihub22266oqcxt.onion/10.3390/genes8020064 C5333053!5333053!28208741     free     free     free       Genes+(Basel) 2017 ; 8 (2): ä Nephropedia Template TP {{tp|p=28208741|t=2017. Mechanisms of Post-Replication DNA Repair |pdf=|usr=}}{{28208741}} gab.com Text Mechanisms of Post-Replication DNA Repair JO: Genes (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=28208741 #FOAvip Accurate DNA replication is crucial for cell survival and the maintenance of genome stability. Cells have developed mechanisms to cope with the frequent genotoxic injuries that arise from both endogenous and environmental sources. Lesions encountered during DNA replication are often tolerated by post-replication repair mechanisms that prevent replication fork collapse and avert the formation of DNA double strand breaks. There are two predominant post-replication repair pathways, trans-lesion synthesis (TLS) and template switching (TS). TLS is a DNA damage-tolerant and low-fidelity mode of DNA synthesis that utilizes specialized ?Y-family? DNA polymerases to replicate damaged templates. TS, however, is an error-free ?DNA damage avoidance? mode of DNA synthesis that uses a newly synthesized sister chromatid as a template in lieu of the damaged parent strand. Both TLS and TS pathways are tightly controlled signaling cascades that integrate DNA synthesis with the overall DNA damage response and are thus crucial for genome stability. This review will cover the current knowledge of the primary mediators of post-replication repair and how they are regulated in the cell. Twit Text FOAVip Mechanisms of Post-Replication DNA Repair ????Genes (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=28208741 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28208741 #FOAvip English Wikipedia <ref>{{Cite pmid|28208741}}</ref> Mechanisms of Post-Replication DNA Repair #MMPMID28208741 Gao Y; Mutter-Rottmayer E; Zlatanou A; Vaziri C; Yang Y Genes (Basel) 2017[Feb]; 8 (2): ä PMID28208741show ga Accurate DNA replication is crucial for cell survival and the maintenance of genome stability. Cells have developed mechanisms to cope with the frequent genotoxic injuries that arise from both endogenous and environmental sources. Lesions encountered during DNA replication are often tolerated by post-replication repair mechanisms that prevent replication fork collapse and avert the formation of DNA double strand breaks. There are two predominant post-replication repair pathways, trans-lesion synthesis (TLS) and template switching (TS). TLS is a DNA damage-tolerant and low-fidelity mode of DNA synthesis that utilizes specialized ?Y-family? DNA polymerases to replicate damaged templates. TS, however, is an error-free ?DNA damage avoidance? mode of DNA synthesis that uses a newly synthesized sister chromatid as a template in lieu of the damaged parent strand. Both TLS and TS pathways are tightly controlled signaling cascades that integrate DNA synthesis with the overall DNA damage response and are thus crucial for genome stability. This review will cover the current knowledge of the primary mediators of post-replication repair and how they are regulated in the cell. äMechanisms of Post-Replication DNA Repair (epmc).pdf DeepDyve Pubget Overpricing