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10.1098/rsif.2016.0877

http://scihub22266oqcxt.onion/10.1098/rsif.2016.0877
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C5332573!5332573!28202590
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suck abstract from ncbi

pmid28202590      J+R+Soc+Interface 2017 ; 14 (127): ä
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  • Advances in multicellular spheroids formation #MMPMID28202590
  • Cui X; Hartanto Y; Zhang H
  • J R Soc Interface 2017[Feb]; 14 (127): ä PMID28202590show ga
  • Three-dimensional multicellular spheroids (MCSs) have a complex architectural structure, dynamic cell?cell/cell?matrix interactions and bio-mimicking in vivo microenvironment. As a fundamental building block for tissue reconstruction, MCSs have emerged as a powerful tool to narrow down the gap between the in vitro and in vivo model. In this review paper, we discussed the structure and biology of MCSs and detailed fabricating methods. Among these methods, the approach in microfluidics with hydrogel support for MCS formation is promising because it allows essential cell?cell/cell?matrix interactions in a confined space.
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