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10.1016/j.cell.2017.01.019 http://scihub22266oqcxt.onion/10.1016/j.cell.2017.01.019 C5332558!5332558 !28215706     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28215706 &cmd=llinks): Failed to open stream: HTTP request failed! 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UV Irradiation Induces a Non-coding RNA that Functionally Opposes the Protein Encoded by the Same Gene |pdf=|usr=}}{{28215706 }} gab.com Text UV Irradiation Induces a Non-coding RNA that Functionally Opposes the Protein Encoded by the Same Gene JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=28215706 #FOAvip The transcription-related DNA damage response was analyzed on a genome-wide scale with great spatial and temporal resolution. Upon UV irradiation, a slowdown of transcript elongation and restriction of gene activity to the promoter-proximal ?25 kb is observed. This is associated with a shift from expression of long mRNAs to shorter isoforms, incorporating alternative last exons (ALEs) that are more proximal to the transcription start site. Notably, this includes a shift from a protein-coding ASCC3 mRNA to a shorter ALE isoform of which the RNA, rather than an encoded protein, is critical for the eventual recovery of transcription. The non-coding ASCC3 isoform counteracts the function of the protein-coding isoform, indicating crosstalk between them. Thus, the ASCC3 gene expresses both coding and non-coding transcript isoforms with opposite effects on transcription recovery after UV-induced DNA damage. Twit Text FOAVip UV Irradiation Induces a Non-coding RNA that Functionally Opposes the Protein Encoded by the Same Gene ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=28215706 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28215706 #FOAvip English Wikipedia <ref>{{Cite pmid|28215706 }}</ref> UV Irradiation Induces a Non-coding RNA that Functionally Opposes the Protein Encoded by the Same Gene #MMPMID28215706 Williamson L ; Saponaro M ; Boeing S ; East P ; Mitter R ; Kantidakis T ; Kelly GP ; Lobley A ; Walker J ; Spencer-Dene B ; Howell M ; Stewart A ; Svejstrup JQ Cell 2017[Feb]; 168 (5 ): 843-855.e13 PMID28215706 show ga The transcription-related DNA damage response was analyzed on a genome-wide scale with great spatial and temporal resolution. Upon UV irradiation, a slowdown of transcript elongation and restriction of gene activity to the promoter-proximal ?25 kb is observed. This is associated with a shift from expression of long mRNAs to shorter isoforms, incorporating alternative last exons (ALEs) that are more proximal to the transcription start site. Notably, this includes a shift from a protein-coding ASCC3 mRNA to a shorter ALE isoform of which the RNA, rather than an encoded protein, is critical for the eventual recovery of transcription. The non-coding ASCC3 isoform counteracts the function of the protein-coding isoform, indicating crosstalk between them. Thus, the ASCC3 gene expresses both coding and non-coding transcript isoforms with opposite effects on transcription recovery after UV-induced DNA damage. |*Transcription, Genetic [MESH] |*Ultraviolet Rays [MESH] |Alternative Splicing/*radiation effects [MESH] |Cell Line [MESH] |DNA Helicases/*genetics [MESH] |Exons [MESH] |Humans [MESH] |RNA Polymerase II/metabolism [MESH] |RNA, Messenger/genetics/metabolism [MESH] |RNA, Untranslated/*genetics [MESH] |Transcription Elongation, Genetic/radiation effects [MESH]UV Irradiation Induces a Non-coding RNA that Functionally Opposes the (epmc).pdf DeepDyve Pubget Overpricing