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2015 ; 9
(12
): 1535-47
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Helicobacter pylori virulence genes and host genetic polymorphisms as risk
factors for peptic ulcer disease
#MMPMID26470920
Miftahussurur M
; Yamaoka Y
Expert Rev Gastroenterol Hepatol
2015[]; 9
(12
): 1535-47
PMID26470920
show ga
Helicobacter pylori infection plays an important role in the pathogenesis of
peptic ulcer disease (PUD). Several factors have been proposed as possible H.
pylori virulence determinants; for example, bacterial adhesins and gastric
inflammation factors are associated with an increased risk of PUD. However,
differences in bacterial virulence factors alone cannot explain the opposite ends
of the PUD disease spectrum, that is duodenal and gastric ulcers; presumably,
both bacterial and host factors contribute to the differential response. Carriers
of the high-producer alleles of the pro-inflammatory cytokines IL-1B, IL-6, IL-8,
IL-10, and TNF-? who also carry low-producer allele of anti-inflammatory
cytokines have severe gastric mucosal inflammation, whereas carriers of the
alternative alleles have mild inflammation. Recent reports have suggested that
the PSCA and CYP2C19 ultra-rapid metabolizer genotypes are also associated with
PUD.