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10.1615/JEnvironPatholToxicolOncol.2016016903 http://scihub22266oqcxt.onion/10.1615/JEnvironPatholToxicolOncol.2016016903 C5332141!5332141!27481495     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27481495&cmd=llinks): Failed to open stream: HTTP request failed! 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Activating Photodynamic Therapy in vitro with Cerenkov Radiation Generated from Yttrium-90 |pdf=|usr=}}{{27481495}} gab.com Text Activating Photodynamic Therapy in vitro with Cerenkov Radiation Generated from Yttrium-90 JO: J Environ Pathol Toxicol Oncol http://www.kidney.de/pget.php?&tw=1&pmid=27481495 #FOAvip The translation of photodynamic therapy (PDT) to the clinical setting has primarily been limited to easily accessible and/or superficial diseases, for which traditional light delivery can be performed noninvasively. Cerenkov radiation, as generated from medically relevant radionuclides, has been suggested as a means to deliver light to deeper tissues noninvasively to overcome this depth limitation. This article investigates the utility of Cerenkov radiation, as generated from the radionuclide yttrium-90, for activating the PDT process using clinically approved aminolevulinic acid at 1.0 mm and also the more efficient porphyrin-based photosensitizer mesotetraphenylporphine with two sulfonate groups on adjacent phenyl rings (TPPS2a) at 1.2 ?M. Experiments were conducted with monolayer cultured glioma and breast tumor cell lines. Although aminolevulinic acid proved to be ineffective for generating a therapeutic effect at all but the highest activity levels, TPPS2a produced at least a 20% therapeutic effect at activities ranging from 6 to 60 ?Ci/well for the C6 glioma cell line. Importantly, these results demonstrate for the first time, to our knowledge, that Cerenkov radiation generated from a radionuclide can be used to activate PDT using clinically relevant photosensitizers. These results therefore provide evidence that it may be possible to generate a phototherapeutic effect in vivo using Cerenkov radiation and clinically relevant photosensitizers. Twit Text FOAVip Activating Photodynamic Therapy in vitro with Cerenkov Radiation Generated from Yttrium-90 ????J Environ Pathol Toxicol Oncol http://www.kidney.de/pget.php?&tw=1&pmid=27481495 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27481495 #FOAvip English Wikipedia <ref>{{Cite pmid|27481495}}</ref> Activating Photodynamic Therapy in vitro with Cerenkov Radiation Generated from Yttrium-90 #MMPMID27481495 Hartl BA; Hirschberg H; Marcu L; Cherry SR J Environ Pathol Toxicol Oncol 2016[]; 35 (2): 185-92 PMID27481495show ga The translation of photodynamic therapy (PDT) to the clinical setting has primarily been limited to easily accessible and/or superficial diseases, for which traditional light delivery can be performed noninvasively. Cerenkov radiation, as generated from medically relevant radionuclides, has been suggested as a means to deliver light to deeper tissues noninvasively to overcome this depth limitation. This article investigates the utility of Cerenkov radiation, as generated from the radionuclide yttrium-90, for activating the PDT process using clinically approved aminolevulinic acid at 1.0 mm and also the more efficient porphyrin-based photosensitizer mesotetraphenylporphine with two sulfonate groups on adjacent phenyl rings (TPPS2a) at 1.2 ?M. Experiments were conducted with monolayer cultured glioma and breast tumor cell lines. Although aminolevulinic acid proved to be ineffective for generating a therapeutic effect at all but the highest activity levels, TPPS2a produced at least a 20% therapeutic effect at activities ranging from 6 to 60 ?Ci/well for the C6 glioma cell line. Importantly, these results demonstrate for the first time, to our knowledge, that Cerenkov radiation generated from a radionuclide can be used to activate PDT using clinically relevant photosensitizers. These results therefore provide evidence that it may be possible to generate a phototherapeutic effect in vivo using Cerenkov radiation and clinically relevant photosensitizers. äActivating Photodynamic Therapy in vitro with Cerenkov Radiation Gener(epmc).pdf DeepDyve Pubget Overpricing