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10.1080/21541248.2016.1194952 http://scihub22266oqcxt.onion/10.1080/21541248.2016.1194952 C5331892!5331892!27248291     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Small+GTPases 2017 ; 8 (1): 49-57 Nephropedia Template TP {{tp|p=27248291|t=2017. Cdc42 regulates Cdc42EP3 function in cancer-associated fibroblasts |pdf=|usr=}}{{27248291}} gab.com Text Cdc42 regulates Cdc42EP3 function in cancer-associated fibroblasts JO: Small GTPases http://www.kidney.de/pget.php?&tw=1&pmid=27248291 #FOAvip Rho family GTPases such as Cdc42 are key regulators of essential cellular processes through their effects on cytoskeletal dynamics, signaling and gene expression. Rho GTPases modulate these functions by engaging a wide variety of downstream effectors. Among these effectors is the largely understudied Cdc42EP/BORG family of Cdc42 effectors. BORG proteins have been linked to actin and septin regulation, but their role in development and disease is only starting to emerge. Recently, Cdc42EP3/BORG2 was shown to coordinate actin and septin cytoskeleton rearrangements in cancer-associated fibroblasts (CAFs). Interestingly, Cdc42EP3 expression potentiated cellular responses to mechanical stimulation leading to signaling and transcriptional adaptations required for the emergence of a fully activated CAF phenotype. These findings uncover a novel role for the BORG/septin network in cancer. Here, we demonstrate that Cdc42EP3 function in CAFs relies on tight regulation by Cdc42. Twit Text FOAVip Cdc42 regulates Cdc42EP3 function in cancer-associated fibroblasts ????Small GTPases http://www.kidney.de/pget.php?&tw=1&pmid=27248291 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27248291 #FOAvip English Wikipedia <ref>{{Cite pmid|27248291}}</ref> Cdc42 regulates Cdc42EP3 function in cancer-associated fibroblasts #MMPMID27248291 Farrugia AJ; Calvo F Small GTPases 2017[]; 8 (1): 49-57 PMID27248291show ga Rho family GTPases such as Cdc42 are key regulators of essential cellular processes through their effects on cytoskeletal dynamics, signaling and gene expression. Rho GTPases modulate these functions by engaging a wide variety of downstream effectors. Among these effectors is the largely understudied Cdc42EP/BORG family of Cdc42 effectors. BORG proteins have been linked to actin and septin regulation, but their role in development and disease is only starting to emerge. Recently, Cdc42EP3/BORG2 was shown to coordinate actin and septin cytoskeleton rearrangements in cancer-associated fibroblasts (CAFs). Interestingly, Cdc42EP3 expression potentiated cellular responses to mechanical stimulation leading to signaling and transcriptional adaptations required for the emergence of a fully activated CAF phenotype. These findings uncover a novel role for the BORG/septin network in cancer. Here, we demonstrate that Cdc42EP3 function in CAFs relies on tight regulation by Cdc42. äCdc42 regulates Cdc42EP3 function in cancer-associated fibroblasts (epmc).pdf DeepDyve Pubget Overpricing