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10.3390/toxins9020044 http://scihub22266oqcxt.onion/10.3390/toxins9020044 C5331424!5331424!28165371     free     free     free       Toxins+(Basel) 2017 ; 9 (2): ä Nephropedia Template TP {{tp|p=28165371|t=2017. Protection against Shiga Toxins |pdf=|usr=}}{{28165371}} gab.com Text Protection against Shiga Toxins JO: Toxins (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=28165371 #FOAvip Shiga toxins consist of an A-moiety and five B-moieties able to bind the neutral glycosphingolipid globotriaosylceramide (Gb3) on the cell surface. To intoxicate cells efficiently, the toxin A-moiety has to be cleaved by furin and transported retrogradely to the Golgi apparatus and to the endoplasmic reticulum. The enzymatically active part of the A-moiety is then translocated to the cytosol, where it inhibits protein synthesis and in some cell types induces apoptosis. Protection of cells can be provided either by inhibiting binding of the toxin to cells or by interfering with any of the subsequent steps required for its toxic effect. In this article we provide a brief overview of the interaction of Shiga toxins with cells, describe some compounds and conditions found to protect cells against Shiga toxins, and discuss whether they might also provide protection in animals and humans. Twit Text FOAVip Protection against Shiga Toxins ????Toxins (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=28165371 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28165371 #FOAvip English Wikipedia <ref>{{Cite pmid|28165371}}</ref> Protection against Shiga Toxins #MMPMID28165371 Kavaliauskiene S; Dyve Lingelem AB; Skotland T; Sandvig K Toxins (Basel) 2017[Feb]; 9 (2): ä PMID28165371show ga Shiga toxins consist of an A-moiety and five B-moieties able to bind the neutral glycosphingolipid globotriaosylceramide (Gb3) on the cell surface. To intoxicate cells efficiently, the toxin A-moiety has to be cleaved by furin and transported retrogradely to the Golgi apparatus and to the endoplasmic reticulum. The enzymatically active part of the A-moiety is then translocated to the cytosol, where it inhibits protein synthesis and in some cell types induces apoptosis. Protection of cells can be provided either by inhibiting binding of the toxin to cells or by interfering with any of the subsequent steps required for its toxic effect. In this article we provide a brief overview of the interaction of Shiga toxins with cells, describe some compounds and conditions found to protect cells against Shiga toxins, and discuss whether they might also provide protection in animals and humans. äProtection against Shiga Toxins (epmc).pdf DeepDyve Pubget Overpricing