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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Anatol+J+Cardiol
2016 ; 16
(9
): 648-54
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Protective effects of aspirin and vitamin C against corn syrup
consumption-induced cardiac damage through sirtuin-1 and HIF-1? pathway
#MMPMID26645266
A?c? H
; Sayg?n M
; Ye?ilot ?
; Topsakal ?
; Cankara FN
; Özmen Ö
; Savran M
Anatol J Cardiol
2016[Sep]; 16
(9
): 648-54
PMID26645266
show ga
OBJECTIVE: The aim of this study was to investigate the protective effects of
aspirin (AS) and vitamin C (VC) against cardiac damage induced by chronic corn
syrup (CS) consumption via a mechanism involving sirtuin-1 (ST-1),
hypoxia-inducible factor-1? (HIF-1?), and the caspase-3 pathway in rats. METHODS:
Forty male Sprague-Dawley rats (14-16 weeks) that weighed 250-300 g were randomly
distributed into 5 groups, each containing 8 rats: control group, CS+AS group,
CS+VC group, CS+AS+VC group, and CS group. AS (10 mg/kg/day) and VC (200
mg/kg/day) were orally given to the rats. F30 (30% fructose syrup solution) was
given to the rats in drinking water for 6 weeks. The rats were sacrificed by
exsanguination 24 h after the last administration. Blood samples and tissue were
collected for biochemical, histopathological, and immunohistochemical
examinations. Non-parametric Kruskal-Wallis test and Mann-Whitney U test used for
the parameters without normal distribution and ANOVA and post-hoc LSD tests were
used for parameters with a normal distribution to compare groups. RESULTS: Uric
acid, creatine kinase (CKMB), and lactate dehydrogenase (LDH) levels were
increased in the CS group compared with the control group (1.45±0.39 and p=0.011;
3225.64±598.25 and p=0.004; 3906.83±1064.22 and p=0.002, respectively) and
decreased in all the treatment groups. In addition, increased levels of MDA and
decreased activity of CAT in the CS group (0.172±0.03 and p=0.000; 0.070±0.005
and p=0.007, respectively) were reversed with AS and VC therapy. A decrease in
ST-1 activity and increases in caspase-3 and HIF-1 activities corrected by VC and
AS therapy were observed. CONCLUSION: AS and VC, which display antioxidant and
antiapoptotic activities, ameliorated cardiac damage induced by chronic fructose
consumption by increasing the levels of ST-1 and decreasing the levels of HIF-1?
and caspase-3.
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