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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Front+Microbiol
2017 ; 8
(ä): 276
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Apoptosis, Toll-like, RIG-I-like and NOD-like Receptors Are Pathways Jointly
Induced by Diverse Respiratory Bacterial and Viral Pathogens
#MMPMID28298903
Martínez I
; Oliveros JC
; Cuesta I
; de la Barrera J
; Ausina V
; Casals C
; de Lorenzo A
; García E
; García-Fojeda B
; Garmendia J
; González-Nicolau M
; Lacoma A
; Menéndez M
; Moranta D
; Nieto A
; Ortín J
; Pérez-González A
; Prat C
; Ramos-Sevillano E
; Regueiro V
; Rodriguez-Frandsen A
; Solís D
; Yuste J
; Bengoechea JA
; Melero JA
Front Microbiol
2017[]; 8
(ä): 276
PMID28298903
show ga
Lower respiratory tract infections are among the top five leading causes of human
death. Fighting these infections is therefore a world health priority. Searching
for induced alterations in host gene expression shared by several relevant
respiratory pathogens represents an alternative to identify new targets for
wide-range host-oriented therapeutics. With this aim, alveolar macrophages were
independently infected with three unrelated bacterial (Streptococcus pneumoniae,
Klebsiella pneumoniae, and Staphylococcus aureus) and two dissimilar viral
(respiratory syncytial virus and influenza A virus) respiratory pathogens, all of
them highly relevant for human health. Cells were also activated with bacterial
lipopolysaccharide (LPS) as a prototypical pathogen-associated molecular pattern.
Patterns of differentially expressed cellular genes shared by the indicated
pathogens were searched by microarray analysis. Most of the commonly up-regulated
host genes were related to the innate immune response and/or apoptosis, with
Toll-like, RIG-I-like and NOD-like receptors among the top 10 signaling pathways
with over-expressed genes. These results identify new potential broad-spectrum
targets to fight the important human infections caused by the bacteria and
viruses studied here.
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