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10.3748/wjg.v23.i8.1345 http://scihub22266oqcxt.onion/10.3748/wjg.v23.i8.1345 C5330819!5330819 !28293081     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28293081 &cmd=llinks): Failed to open stream: HTTP request failed! 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Autoantibody profiles in autoimmune hepatitis and chronic hepatitis C identifies similarities in patients with severe disease |pdf=|usr=}}{{28293081 }} gab.com Text Autoantibody profiles in autoimmune hepatitis and chronic hepatitis C identifies similarities in patients with severe disease JO: World J Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=28293081 #FOAvip AIM: To determine how the auto-antibodies (Abs) profiles overlap in chronic hepatitis C infection (CHC) and autoimmune hepatitis (AIH) and correlate to liver disease. METHODS: Levels of antinuclear Ab, smooth muscle antibody (SMA) and liver/kidney microsomal-1 (LKM-1) Ab and markers of liver damage were determined in the sera of 50 patients with CHC infection, 20 AIH patients and 20 healthy controls using enzyme linked immunosorbent assay and other immune assays. RESULTS: We found that AIH patients had more severe liver disease as determined by elevation of total IgG, alkaline phosphatase, total serum bilirubin and serum transaminases and significantly higher prevalence of the three non-organ-specific autoantibodies (auto-Abs) than CHC patients. Antinuclear Ab, SMA and LKM-1 Ab were also present in 36% of CHC patients and related to disease severity. CHC cases positive for auto-Abs were directly comparable to AIH in respect of most markers of liver damage and total IgG. These cases had longer disease duration compared with auto-Ab negative cases, but there was no difference in gender, age or viral load. KLM-1(+) Ab CHC cases showed best overlap with AIH. CONCLUSION: Auto-Ab levels in CHC may be important markers of disease severity and positive cases have a disease similar to AIH. Auto-Abs might have a pathogenic role as indicated by elevated markers of liver damage. Future studies will unravel any novel associations between these two diseases, whether genetic or other. Twit Text FOAVip Autoantibody profiles in autoimmune hepatitis and chronic hepatitis C identifies similarities in patients with severe disease ????World J Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=28293081 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28293081 #FOAvip English Wikipedia <ref>{{Cite pmid|28293081 }}</ref> Autoantibody profiles in autoimmune hepatitis and chronic hepatitis C identifies similarities in patients with severe disease #MMPMID28293081 Amin K ; Rasool AH ; Hattem A ; Al-Karboly TA ; Taher TE ; Bystrom J World J Gastroenterol 2017[Feb]; 23 (8 ): 1345-1352 PMID28293081 show ga AIM: To determine how the auto-antibodies (Abs) profiles overlap in chronic hepatitis C infection (CHC) and autoimmune hepatitis (AIH) and correlate to liver disease. METHODS: Levels of antinuclear Ab, smooth muscle antibody (SMA) and liver/kidney microsomal-1 (LKM-1) Ab and markers of liver damage were determined in the sera of 50 patients with CHC infection, 20 AIH patients and 20 healthy controls using enzyme linked immunosorbent assay and other immune assays. RESULTS: We found that AIH patients had more severe liver disease as determined by elevation of total IgG, alkaline phosphatase, total serum bilirubin and serum transaminases and significantly higher prevalence of the three non-organ-specific autoantibodies (auto-Abs) than CHC patients. Antinuclear Ab, SMA and LKM-1 Ab were also present in 36% of CHC patients and related to disease severity. CHC cases positive for auto-Abs were directly comparable to AIH in respect of most markers of liver damage and total IgG. These cases had longer disease duration compared with auto-Ab negative cases, but there was no difference in gender, age or viral load. KLM-1(+) Ab CHC cases showed best overlap with AIH. CONCLUSION: Auto-Ab levels in CHC may be important markers of disease severity and positive cases have a disease similar to AIH. Auto-Abs might have a pathogenic role as indicated by elevated markers of liver damage. Future studies will unravel any novel associations between these two diseases, whether genetic or other. |Adolescent [MESH] |Adult [MESH] |Aged [MESH] |Autoantibodies/*immunology/metabolism [MESH] |Case-Control Studies [MESH] |Child [MESH] |Disease Progression [MESH] |Enzyme-Linked Immunosorbent Assay [MESH] |Female [MESH] |Hepatitis C, Chronic/blood/*diagnosis/*immunology [MESH] |Hepatitis, Autoimmune/blood/*diagnosis/*immunology [MESH] |Humans [MESH] |Immunoglobulin G/immunology [MESH] |Male [MESH] |Middle Aged [MESH] |Muscle, Smooth/metabolism [MESH] |Sex Factors [MESH]Autoantibody profiles in autoimmune hepatitis and chronic hepatitis C (epmc).pdf DeepDyve Pubget Overpricing