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2017 ; 93
(4
): 767-776.e6
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Different Modes of Visual Integration in the Lateral Geniculate Nucleus Revealed
by Single-Cell-Initiated Transsynaptic Tracing
#MMPMID28231464
Rompani SB
; Müllner FE
; Wanner A
; Zhang C
; Roth CN
; Yonehara K
; Roska B
Neuron
2017[Feb]; 93
(4
): 767-776.e6
PMID28231464
show ga
The thalamus receives sensory input from different circuits in the periphery. How
these sensory channels are integrated at the level of single thalamic cells is
not well understood. We performed targeted single-cell-initiated transsynaptic
tracing to label the retinal ganglion cells that provide input to individual
principal cells in the mouse lateral geniculate nucleus (LGN). We identified
three modes of sensory integration by single LGN cells. In the first, 1-5
ganglion cells of mostly the same type converged from one eye, indicating a relay
mode. In the second, 6-36 ganglion cells of different types converged from one
eye, revealing a combination mode. In the third, up to 91 ganglion cells
converged from both eyes, revealing a binocular combination mode in which
functionally specialized ipsilateral inputs joined broadly distributed
contralateral inputs. Thus, the LGN employs at least three modes of visual input
integration, each exhibiting different degrees of specialization.