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10.1177/1756283X16672392 http://scihub22266oqcxt.onion/10.1177/1756283X16672392 C5330612!5330612 !28286560     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28286560 &cmd=llinks): Failed to open stream: HTTP request failed! 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Prevalence of end of treatment RNA-positive/sustained viral response in HCV patients treated with sofosbuvir combination therapies |pdf=|usr=}}{{28286560 }} gab.com Text Prevalence of end of treatment RNA-positive/sustained viral response in HCV patients treated with sofosbuvir combination therapies JO: Therap Adv Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=28286560 #FOAvip BACKGROUND: Some chronic hepatitis C virus (HCV), genotype 1 infected patients treated with direct antiviral agents (DAAs) remain viremic at end of treatment (EOT+), yet go on to achieve sustained virological response 12?weeks after completion of therapy (SVR(12)). The incidence of EOT+/SVR in patients with genotype 1 and other genotypes, as well as whether such patients achieve SVR(24) remain in question. The aims of this study were to evaluate the frequency and durability of EOT+/SVR(12&24) and other response categories in HCV genotype 1, 2, or 3 infected patients treated with DAA in clinical practice. METHODS: Data from patients treated with all oral sofosbuvir-based regimens at a university hepatology practice by 1 July 2015 were reviewed retrospectively. Responses were categorized based on virus levels during and post DAA treatment. HCV RNA levels were measured by Abbott RealTime HCV (ART) or by Roche CobasTaqMan v2.0 (RCTM) assays. RESULTS: The study population included 89 patients. Participants were 62% genotype 1, 19% genotype 2 and 19% genotype 3, 54% cirrhotic and 46% treatment-experienced. A total of 45 received sofosbuvir-simeprevir, 38 sofosbuvir-ribavirin and 6 sofosbuvir-ledipasvir. The SVR(12) rate was 82%. A total of 5 patients (6%), all with genotype 1, had EOT+ by ART assay and each achieved SVR(12&24). CONCLUSIONS: A total of 9% of genotype 1 patients (6% overall) treated with DAAs were EOT+ by ART and all EOT+ cases achieved SVR(24). EOT+/SVR was not observed with genotype 2 or 3 or by the RCTM assay. In patients treated with DAAs, EOT+ by the ART assay does not indicate treatment failure. Twit Text FOAVip Prevalence of end of treatment RNA-positive/sustained viral response in HCV patients treated with sofosbuvir combination therapies ????Therap Adv Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=28286560 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28286560 #FOAvip English Wikipedia <ref>{{Cite pmid|28286560 }}</ref> Prevalence of end of treatment RNA-positive/sustained viral response in HCV patients treated with sofosbuvir combination therapies #MMPMID28286560 Malespin M ; Benyashvili T ; Uprichard SL ; Perelson AS ; Dahari H ; Cotler SJ Therap Adv Gastroenterol 2017[Jan]; 10 (1 ): 68-73 PMID28286560 show ga BACKGROUND: Some chronic hepatitis C virus (HCV), genotype 1 infected patients treated with direct antiviral agents (DAAs) remain viremic at end of treatment (EOT+), yet go on to achieve sustained virological response 12?weeks after completion of therapy (SVR(12)). The incidence of EOT+/SVR in patients with genotype 1 and other genotypes, as well as whether such patients achieve SVR(24) remain in question. The aims of this study were to evaluate the frequency and durability of EOT+/SVR(12&24) and other response categories in HCV genotype 1, 2, or 3 infected patients treated with DAA in clinical practice. METHODS: Data from patients treated with all oral sofosbuvir-based regimens at a university hepatology practice by 1 July 2015 were reviewed retrospectively. Responses were categorized based on virus levels during and post DAA treatment. HCV RNA levels were measured by Abbott RealTime HCV (ART) or by Roche CobasTaqMan v2.0 (RCTM) assays. RESULTS: The study population included 89 patients. Participants were 62% genotype 1, 19% genotype 2 and 19% genotype 3, 54% cirrhotic and 46% treatment-experienced. A total of 45 received sofosbuvir-simeprevir, 38 sofosbuvir-ribavirin and 6 sofosbuvir-ledipasvir. The SVR(12) rate was 82%. A total of 5 patients (6%), all with genotype 1, had EOT+ by ART assay and each achieved SVR(12&24). CONCLUSIONS: A total of 9% of genotype 1 patients (6% overall) treated with DAAs were EOT+ by ART and all EOT+ cases achieved SVR(24). EOT+/SVR was not observed with genotype 2 or 3 or by the RCTM assay. In patients treated with DAAs, EOT+ by the ART assay does not indicate treatment failure. äPrevalence of end of treatment RNA-positive/sustained viral response i(epmc).pdf DeepDyve Pubget Overpricing