Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28286563
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Therap+Adv+Gastroenterol
2017 ; 10
(1
): 101-113
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Antispasmodic drugs in colonoscopy: a review of their pharmacology, safety and
efficacy in improving polyp detection and related outcomes
#MMPMID28286563
Sanagapalli S
; Agnihotri K
; Leong R
; Corte CJ
Therap Adv Gastroenterol
2017[Jan]; 10
(1
): 101-113
PMID28286563
show ga
Antispasmodic drugs are cheap, effective and generally safe. They may improve
outcomes in colonoscopy, however their use has not been consistent or widespread.
This manuscript reviews the three most commonly used antispasmodics in
colonoscopy, namely, hyoscine butylbromide (and related ammonium compounds),
glucagon and peppermint oil. The pharmacology, action and safety of the agents,
as well as the evidence for them improving colonoscopic outcomes will be
discussed. In addition to polyp detection, other colonoscopic outcome endpoints
of interest include cecal and ileal intubation, and patient comfort. The drugs
studied were all found to be effective gastrointestinal antispasmodics with good
safety profiles. There is insufficient evidence to conclude whether
antispasmodics improve cecal intubation rate, predominantly because the baseline
rates are already high. Antispasmodics probably have efficacy in reducing cecal
intubation time especially in those with marked colonic spasm. Antispasmodics do
not offer significant benefit in polyp detection or improving patient comfort
during colonoscopy. Future studies should focus on inexperienced colonoscopists
as well as those with marked colonic spasm, in whom the greatest benefit seems to
lie.