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10.1186/s13287-017-0498-1 http://scihub22266oqcxt.onion/10.1186/s13287-017-0498-1 C5330084!5330084!28241890     free     free     free       Stem+Cell+Res+Ther 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28241890|t=2017. p53 switches off pluripotency on differentiation |pdf=|usr=}}{{28241890}} gab.com Text p53 switches off pluripotency on differentiation JO: Stem Cell Res Ther http://www.kidney.de/pget.php?&tw=1&pmid=28241890 #FOAvip The role of p53 as ?a guardian of the genome? has been well established in somatic cells. However, its role in pluripotent stem cells remains much more elusive. Here, we discuss research progress in understanding the role of p53 in pluripotent stem cells and in pluripotent stem cell-like cancer stem cells. The p53 protein, which plays a key role in embryonic stem cells, was first discovered in 2005. Landmark studies of p53-related reprogramming elucidated this protein?s importance in induced pluripotent stem cells in 2009. The p53-related safety concerns in pluripotent stem cells have been raised in stem cell-based therapy although the use of iPSCs in therapeutic application is promising. Because cancer stem cells have profiles similar to those of pluripotent stem cells, we also describe potential strategies for studies in cancer stem cells and cancer treatments. The new discoveries of p53 family proteins in pluripotent stem cells have made possible stable progress in stem cell transplantation efficiency and safety, as well as treatment strategies targeting cancer stem cells based on pluripotent stem cell technology. Twit Text FOAVip p53 switches off pluripotency on differentiation ????Stem Cell Res Ther http://www.kidney.de/pget.php?&tw=1&pmid=28241890 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28241890 #FOAvip English Wikipedia <ref>{{Cite pmid|28241890}}</ref> p53 switches off pluripotency on differentiation #MMPMID28241890 Lin T; Lin Y Stem Cell Res Ther 2017[]; 8 (ä): ä PMID28241890show ga The role of p53 as ?a guardian of the genome? has been well established in somatic cells. However, its role in pluripotent stem cells remains much more elusive. Here, we discuss research progress in understanding the role of p53 in pluripotent stem cells and in pluripotent stem cell-like cancer stem cells. The p53 protein, which plays a key role in embryonic stem cells, was first discovered in 2005. Landmark studies of p53-related reprogramming elucidated this protein?s importance in induced pluripotent stem cells in 2009. The p53-related safety concerns in pluripotent stem cells have been raised in stem cell-based therapy although the use of iPSCs in therapeutic application is promising. Because cancer stem cells have profiles similar to those of pluripotent stem cells, we also describe potential strategies for studies in cancer stem cells and cancer treatments. The new discoveries of p53 family proteins in pluripotent stem cells have made possible stable progress in stem cell transplantation efficiency and safety, as well as treatment strategies targeting cancer stem cells based on pluripotent stem cell technology. äp53 switches off pluripotency on differentiation (epmc).pdf DeepDyve Pubget Overpricing