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10.1111/cas.13120 http://scihub22266oqcxt.onion/10.1111/cas.13120 C5329158!5329158!27865045     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Sci 2017 ; 108 (2): 178-86 Nephropedia Template TP {{tp|p=27865045|t=2017. High KRT8 expression promotes tumor progression and metastasis of gastric cancer |pdf=|usr=}}{{27865045}} gab.com Text High KRT8 expression promotes tumor progression and metastasis of gastric cancer JO: Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=27865045 #FOAvip Keratin8 (KRT8) is the major component of the intermediate filament cytoskeleton and predominantly expressed in simple epithelial tissues. Aberrant expression of KRT8 is associated with multiple tumor progression and metastasis. However, the role of KRT8 in gastric cancer (GC) remains unclear. In this study, KRT8 expression was investigated and it was found to be upregulated along with human GC progression and metastasis at both mRNA and protein levels in human gastric cancer tissues. In addition, KRT8 overexpression enhanced the proliferation and migration of human gastric cancer cells, whereas the knock?down of KRT8 by siRNA only inhibited migration of human gastric cancer cells. Integrin?1?FAK?induced epithelial?mesenchymal?transition (EMT) only existed in the high KRT8 cells. Furthermore, KRT8 overexpression led to increase in p?smad2/3 levels and TGF? dependent signaling events. KRT8 expression in GC was related to tumor clinical stage and worse survival. Kaplan?Meier analysis proved that KRT8 was associated with overall survival of patients with GC that patients with high KRT8 expression tend to have unfavorable outcome. Moreover, Cox's proportional hazards analysis showed that high KRT8 expression was a prognostic marker of poor outcome. These results provided that KRT8 expression may therefore be a biomarker or potential therapeutic target to identify patients with worse survival. Twit Text FOAVip High KRT8 expression promotes tumor progression and metastasis of gastric cancer ????Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=27865045 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27865045 #FOAvip English Wikipedia <ref>{{Cite pmid|27865045}}</ref> High KRT8 expression promotes tumor progression and metastasis of gastric cancer #MMPMID27865045 Fang J; Wang H; Liu Y; Ding F; Ni Y; Shao S Cancer Sci 2017[Feb]; 108 (2): 178-86 PMID27865045show ga Keratin8 (KRT8) is the major component of the intermediate filament cytoskeleton and predominantly expressed in simple epithelial tissues. Aberrant expression of KRT8 is associated with multiple tumor progression and metastasis. However, the role of KRT8 in gastric cancer (GC) remains unclear. In this study, KRT8 expression was investigated and it was found to be upregulated along with human GC progression and metastasis at both mRNA and protein levels in human gastric cancer tissues. In addition, KRT8 overexpression enhanced the proliferation and migration of human gastric cancer cells, whereas the knock?down of KRT8 by siRNA only inhibited migration of human gastric cancer cells. Integrin?1?FAK?induced epithelial?mesenchymal?transition (EMT) only existed in the high KRT8 cells. Furthermore, KRT8 overexpression led to increase in p?smad2/3 levels and TGF? dependent signaling events. KRT8 expression in GC was related to tumor clinical stage and worse survival. Kaplan?Meier analysis proved that KRT8 was associated with overall survival of patients with GC that patients with high KRT8 expression tend to have unfavorable outcome. Moreover, Cox's proportional hazards analysis showed that high KRT8 expression was a prognostic marker of poor outcome. These results provided that KRT8 expression may therefore be a biomarker or potential therapeutic target to identify patients with worse survival. äHigh KRT8 expression promotes tumor progression and metastasis of gast(epmc).pdf DeepDyve Pubget Overpricing