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10.3389/fimmu.2017.00170 http://scihub22266oqcxt.onion/10.3389/fimmu.2017.00170 C5328996!5328996!28293238     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28293238|t=2017. Role of Memory T Cells in Allograft Rejection and Tolerance |pdf=|usr=}}{{28293238}} gab.com Text Role of Memory T Cells in Allograft Rejection and Tolerance JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28293238 #FOAvip Memory T cells are characterized by their low activation threshold, robust effector functions, and resistance to conventional immunosuppression and costimulation blockade. Unlike their naïve counterparts, memory T cells reside in and recirculate through peripheral non-lymphoid tissues. Alloreactive memory T cells are subdivided into different categories based on their origins, phenotypes, and functions. Recipients whose immune systems have been directly exposed to allogeneic major histocompatibility complex (MHC) molecules display high affinity alloreactive memory T cells. In the absence of any prior exposure to allogeneic MHC molecules, endogenous alloreactive memory T cells are regularly generated through microbial infections (heterologous immunity). Regardless of their origin, alloreactive memory T cells represent an essential element of the allograft rejection process and a major barrier to tolerance induction in clinical transplantation. This article describes the different subsets of alloreactive memory T cells involved in transplant rejection and examine their generation, functional properties, and mechanisms of action. In addition, we discuss strategies developed to target deleterious allospecific memory T cells in experimental animal models and clinical settings. Twit Text FOAVip Role of Memory T Cells in Allograft Rejection and Tolerance ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28293238 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28293238 #FOAvip English Wikipedia <ref>{{Cite pmid|28293238}}</ref> Role of Memory T Cells in Allograft Rejection and Tolerance #MMPMID28293238 Benichou G; Gonzalez B; Marino J; Ayasoufi K; Valujskikh A Front Immunol 2017[]; 8 (ä): ä PMID28293238show ga Memory T cells are characterized by their low activation threshold, robust effector functions, and resistance to conventional immunosuppression and costimulation blockade. Unlike their naïve counterparts, memory T cells reside in and recirculate through peripheral non-lymphoid tissues. Alloreactive memory T cells are subdivided into different categories based on their origins, phenotypes, and functions. Recipients whose immune systems have been directly exposed to allogeneic major histocompatibility complex (MHC) molecules display high affinity alloreactive memory T cells. In the absence of any prior exposure to allogeneic MHC molecules, endogenous alloreactive memory T cells are regularly generated through microbial infections (heterologous immunity). Regardless of their origin, alloreactive memory T cells represent an essential element of the allograft rejection process and a major barrier to tolerance induction in clinical transplantation. This article describes the different subsets of alloreactive memory T cells involved in transplant rejection and examine their generation, functional properties, and mechanisms of action. In addition, we discuss strategies developed to target deleterious allospecific memory T cells in experimental animal models and clinical settings. äRole of Memory T Cells in Allograft Rejection and Tolerance (epmc).pdf DeepDyve Pubget Overpricing