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10.3389/fmicb.2017.00303 http://scihub22266oqcxt.onion/10.3389/fmicb.2017.00303 C5328978!5328978!28293227     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Microbiol 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28293227|t=2017. MLKL Mediated Necroptosis Accelerates JEV-Induced Neuroinflammation in Mice |pdf=|usr=}}{{28293227}} gab.com Text MLKL Mediated Necroptosis Accelerates JEV-Induced Neuroinflammation in Mice JO: Front Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=28293227 #FOAvip Japanese encephalitis virus (JEV) is the most prevalent cause of viral encephalitis in Asia and the western Pacific. Neuronal death caused by JEV infection and inflammation induced cytotoxicity leads to progression and deterioration of Japanese encephalitis (JE). Mixed-lineage kinase domain-like protein (MLKL) mediated necroptosis is a newly discovered pathway of programmed cell death and participates in many inflammatory diseases. In this study, we demonstrated for the first time that necroptosis was involved in the neuronal loss during JE via immune-electron microscopy and immunochemistry. The expression of MLKL in neurons was upregulated in presence of JEV infection in vitro and in vivo. Deletion of MLKL alleviated the progression of JE and decreased the level of inflammatory cytokines in mice model. Taken together, this study provides evidence for the participation of necroptosis in the pathogenesis of JEV infection. Twit Text FOAVip MLKL Mediated Necroptosis Accelerates JEV-Induced Neuroinflammation in Mice ????Front Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=28293227 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28293227 #FOAvip English Wikipedia <ref>{{Cite pmid|28293227}}</ref> MLKL Mediated Necroptosis Accelerates JEV-Induced Neuroinflammation in Mice #MMPMID28293227 Bian P; Zheng X; Wei L; Ye C; Fan H; Cai Y; Zhang Y; Zhang F; Jia Z; Lei Y Front Microbiol 2017[]; 8 (ä): ä PMID28293227show ga Japanese encephalitis virus (JEV) is the most prevalent cause of viral encephalitis in Asia and the western Pacific. Neuronal death caused by JEV infection and inflammation induced cytotoxicity leads to progression and deterioration of Japanese encephalitis (JE). Mixed-lineage kinase domain-like protein (MLKL) mediated necroptosis is a newly discovered pathway of programmed cell death and participates in many inflammatory diseases. In this study, we demonstrated for the first time that necroptosis was involved in the neuronal loss during JE via immune-electron microscopy and immunochemistry. The expression of MLKL in neurons was upregulated in presence of JEV infection in vitro and in vivo. Deletion of MLKL alleviated the progression of JE and decreased the level of inflammatory cytokines in mice model. Taken together, this study provides evidence for the participation of necroptosis in the pathogenesis of JEV infection. äMLKL Mediated Necroptosis Accelerates JEV-Induced Neuroinflammation in(epmc).pdf DeepDyve Pubget Overpricing