Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27597148
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Changes in Urinary Microbiome Populations Correlate in Kidney Transplants With
Interstitial Fibrosis and Tubular Atrophy Documented in Early Surveillance
Biopsies
#MMPMID27597148
Modena BD
; Milam R
; Harrison F
; Cheeseman JA
; Abecassis MM
; Friedewald JJ
; Kirk AD
; Salomon DR
Am J Transplant
2017[Mar]; 17
(3
): 712-723
PMID27597148
show ga
An unbalanced microbiome may lead to disease by creating aberrant immune
responses. A recent association of cellular rejection with the development of
interstitial fibrosis and tubular atrophy (IFTA) suggests the role of
immune-mediated tissue injury. We hypothesized that developing IFTA correlates
with altered urinary tract microbiomes (UMBs). UMBs at two serial time points, 1
and 6-8 months posttransplant, were assessed by 16S microbial ribosomal gene
sequencing in 25 patients developing biopsy-proven IFTA compared to 23 transplant
patients with normal biopsies and excellent function (TX) and 20 healthy
nontransplant controls (HC). Streptococcus, the dominant genera in HC males, was
lower in IFTA and TX males at 1 month compared to HCs. At 6-8 months,
Streptococcus was further decreased in IFTA males, but normalized in TX. IFTA
males and females had increases in number of genera per sample at 6-8 months. UMB
composition varied substantially between individuals in all groups. Despite the
wide variation in UMBs between individuals, IFTA was associated with a loss in
dominant resident urinary microbes in males, and a parallel increase in
nonresident, pathogenic bacteria in males and females. UMB changes may contribute
to IFTA development by alteration of the host immune response.
free
free
free
